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Neurones in the CA1 region of the dorsal hippocampus of urethane-anaesthetized rats were recorded extracellularly with microelectrodes, and tested for their response to non-noxious and noxious peripheral stimuli. None of the cells responded to non-noxious stimuli but 91 of 216 cells were excited by noxious stimuli. Morphine (5.0 mg/kg i.v.) increased the(More)
AIM Calculate time to first-line treatment failure, annual cost and cost-effectiveness of NNRTI versus PIboosted first-line HAART regimens in the UK, 1996-2006. BACKGROUND Population costs for HIV services are increasing in the UK and interventions need to be effective and efficient to reduce or stabilize costs. 2NRTIs + NNRTI regimens are cost-effective(More)
1. Cerebellar Purkinje cell unit activity was recorded in urethane or halothane anaesthetized rats. 2. Ethanol (4 g/kg i.p., 30% w/v) increased simple spike activity and decreased complex spike activity. This pattern then changed to one of an oscillatory bursting discharge. 3. The blood ethanol levels were very much higher after doses of 4 g/kg i.p. than(More)
Long-term potentiation (LTP) of the CA1 population spike in the hippocampal slice was produced by a tetanic stimulus in the stratum radiatum or by doubling the calcium concentration in the medium to 4 mM for 10 min. Ethanol (0.1 M) antagonized both tetanic- and ethanol-induced LTP. Since the hippocampus is known to be involved with memory, and ethanol(More)
Ethanol (1 g/kg, iv) produced a peak depression of acetylcholine release from the cat sensorimotor cortices within 30 min of the ethanol administration but recovery to control levels occurred in the following 30 min. However, the concentrations of ethanol in the blood and in the solution bathing the cortex remained stable during this recovery period. This(More)
To test the hypothesis that the hyperpyrexia produced by meperidine and detromethorphan in rabbits pretreated with a monoamine oxidase inhibitor is related to inhibition of neuronal uptake of serotonin (5-hydroxytryptamine (5-HT)), fluoxetine (Lilly 110140) was studied. This potent and specific 5-HT neuronal uptake blocker was administered to(More)
1. Cerebellar Purkinje cell activity was recorded in urethane anaesthetized rats. 2. Flurazepam, infused intravenously in divided doses totalling 4 mg/kg, decreased simple spike activity, increased complex spike activity and prolonged local surface inhibition. 3. Iontophoretically applied flurazepam enhanced the effect of GABA and elicited a bursting(More)
A controversy exists as to whether morphine attenuates spinal cord nociceptive transmission through a supraspinal site of action. The approach of examining the effects of morphine on spinal cord nociceptive transmission in the presence and absence of spinal cord conduction has led to conflicting conclusions. We have compared the effects of morphine on the(More)