Gary Lo

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Neurones in the CA1 region of the dorsal hippocampus of urethane-anaesthetized rats were recorded extracellularly with microelectrodes, and tested for their response to non-noxious and noxious peripheral stimuli. None of the cells responded to non-noxious stimuli but 91 of 216 cells were excited by noxious stimuli. Morphine (5.0 mg/kg i.v.) increased the(More)
Long-term potentiation (LTP) of the CA1 population spike in the hippocampal slice was produced by a tetanic stimulus in the stratum radiatum or by doubling the calcium concentration in the medium to 4 mM for 10 min. Ethanol (0.1 M) antagonized both tetanic- and ethanol-induced LTP. Since the hippocampus is known to be involved with memory, and ethanol(More)
Ethanol (1.5 g/kg i.v.) was found to decrease spontaneous complex spike (CS) activity in cerebellar Purkinje cells in urethane anaesthetized rats while not changing the threshold required to evoke a CS by juxtafastigial stimulation. Thus ethanol does not decrease CS activity by an action at the climbing fibre-Purkinje cell synapse. Tremor induced by(More)
BACKGROUND The number of people living with HIV (PLHIV) is increasing in the UK. This study estimated the annual population cost of providing HIV services in the UK, 1997-2006 and projected them 2007-2013. METHODS Annual cost of HIV treatment for PLHIV by stage of HIV infection and type of ART was calculated (UK pounds, 2006 prices). Population costs were(More)
A controversy exists as to whether morphine attenuates spinal cord nociceptive transmission through a supraspinal site of action. The approach of examining the effects of morphine on spinal cord nociceptive transmission in the presence and absence of spinal cord conduction has led to conflicting conclusions. We have compared the effects of morphine on the(More)
AIM Calculate time to first-line treatment failure, annual cost and cost-effectiveness of NNRTI versus PIboosted first-line HAART regimens in the UK, 1996-2006. BACKGROUND Population costs for HIV services are increasing in the UK and interventions need to be effective and efficient to reduce or stabilize costs. 2NRTIs + NNRTI regimens are cost-effective(More)
To test the hypothesis that the hyperpyrexia produced by meperidine and detromethorphan in rabbits pretreated with a monoamine oxidase inhibitor is related to inhibition of neuronal uptake of serotonin (5-hydroxytryptamine (5-HT)), fluoxetine (Lilly 110140) was studied. This potent and specific 5-HT neuronal uptake blocker was administered to(More)