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One of the major factors limiting the staging accuracy of conventional magnetic resonance imaging (MRI) for prostatic carcinoma, is the similarity in signal intensity between tumor and coexisting benign prostatic hyperplasia (BPH). As neovascularity is an independent indicator of pathological state, dynamic contrast-enhanced MRI may yield additional(More)
The purpose of this work is to assess the additional benefit of MRI-based morphology and quantification of contrast enhancement in the differential diagnosis of sub-1cm breast lesions. Forty-three women with suspected breast cancer were examined using X-ray mammography, ultrasound mammography, and MRI. Dynamic contrast imaging was performed and relative(More)
PURPOSE To compare different imaging methods with single-voxel MR spectroscopy (MRS) for the quantification of fat content in phantoms at 3.0T. MATERIALS AND METHODS Imaging and spectroscopy was performed on a GE Signa system. Eleven novel homogeneous fat-water phantoms were constructed with variation in fat content from 0% to 100%. These were imaged(More)
PURPOSE To evaluate the efficacy of MR Spectroscopy (MRS) at 3.0 Tesla for the assessment of normal bone marrow composition and assess the variation in terms of age, gender, and skeletal site. MATERIALS AND METHODS A total of 16 normal subjects (aged between eight and 57 years) were investigated on a 3.0 Tesla GE Signa system. To investigate axial and(More)
The imaging and analysis protocol of the UK multicentre study of magnetic resonance imaging (MRI) as a method of screening for breast cancer in women at genetic risk is described. The study will compare the sensitivity and specificity of contrast-enhanced MRI with two-view x-ray mammography. Approximately 500 women below the age of 50 at high genetic risk(More)
The quantitation of in vivo 1H MR spectroscopy and dynamic contrast enhanced MR imaging is described for patients with histologically confirmed prostate adenocarcinoma and benign prostatic hypertrophy (BPH). Results are presented which suggest that combined use of these techniques may be helpful in improving the characterization of prostate pathologies and(More)
In this study, diffusion-weighted images of the human prostate were successfully obtained, enabling quantification of apparent diffusion coefficients (ADCs) in normal and pathologic regions. A dual acquisition fast spin-echo sequence was used for accurate T2 calculation. T2 values were significantly higher in the peripheral zone than the central gland (P =(More)
Dynamic contrast-enhanced MR mammography is an increasingly used method of evaluating breast pathology. The purpose of this study was to compare two semi-automated methods of region of interest (ROI) analysis with a user-defined method, in the discrimination of breast tumors using dynamic contrast-enhanced MRI. Results are presented from the retrospective(More)
A commercial phased-array multicoil was used to acquire water-suppressed localized proton spectra of the two major anatomical regions of the prostate. The signal-to-noise ratio and spectral resolution allowed identification of peaks from choline and creatine, as well as a major peak from citrate. Quantification of the citrate peak using experimentally(More)
We have previously reported a striking correlation between water T2 relaxation time and citrate concentration in the normal prostate (Liney G.P.; Lowry M.; Turnbull L.W.; Manton D.J.; Knowles A.J.; Blackband S.J.; Horsman A. Proton MR T2 maps correlate with the citrate concentration in the prostate. NMR Biomed. 9:59-64; 1996). In this study we present data(More)