Gary L. Firestone

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Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway.

Jongsun Park, Meredith L L Leong, Patricia Buse, Anita C. Maiyar, Gary L. Firestone, Brian A. Hemmings
The EMBO journal
1999

Serum and glucocorticoid-inducible kinase (SGK) is a novel member of the serine/threonine protein kinase family that is transcriptionally regulated. In this study, we have investigated the regulatory… (More)

Epithelial sodium channel regulated by aldosterone-induced protein sgk.

S y Chen, Aditi Bhargava, +6 authors David Pearce
Proceedings of the National Academy of Sciences…
1999

Sodium homeostasis in terrestrial and freshwater vertebrates is controlled by the corticosteroid hormones, principally aldosterone, which stimulate electrogenic Na+ absorption in tight epithelia.… (More)

Follicle-Stimulating hormone (FSH) stimulates phosphorylation and activation of protein kinase B (PKB/Akt) and serum and glucocorticoid-lnduced kinase (Sgk): evidence for A kinase-independent…

Ignacio J Gonzalez-Robayna, Allison E Falender, Scott Ochsner, Gary L. Firestone, Joanne S Richards
Molecular endocrinology
2000

FSH stimulates in ovarian granulosa cells diverse, differentiation-dependent responses that implicate activation of specific cellular signaling cascades. In these studies three kinases were… (More)

SGK integrates insulin and mineralocorticoid regulation of epithelial sodium transport.

Joy Wang, Pascal Barbry, +5 authors David Pearce
American journal of physiology. Renal physiology
2001

The epithelial Na+ channel (ENaC) constitutes the rate-limiting step for Na+ transport across tight epithelia and is the principal target of hormonal regulation, particularly by insulin and… (More)

Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: possible role of SGK.

Johannes Loffing, Maja Zecevic, +6 authors Fl. Verrey
American journal of physiology. Renal physiology
2001

Aldosterone controls sodium reabsorption and potassium secretion in the aldosterone-sensitive distal nephron (ASDN). Although clearance measurements have shown that aldosterone induces these… (More)

Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum.

M. H. C. Webster, L. Goya, Yan Ge, Anita C. Maiyar, Gary L. Firestone
Molecular and cellular biology
1993

A novel member of the serine/threonine protein kinase gene family, designated sgk, for serum and glucocorticoid-regulated kinase, was identified in a differential screen for glucocorticoid-inducible… (More)

Stimulus-dependent regulation of serum and glucocorticoid inducible protein kinase (SGK) transcription, subcellular localization and enzymatic activity.

Gary L. Firestone, Jennifer R Giampaolo, B O'keeffe
Cellular physiology and biochemistry…
2003

We originally discovered the serum and glucocorticoid inducible protein kinase, SGK, as a novel protein kinase that is under acute transcriptional control by serum and glucocorticoids. An expanding… (More)

Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest.

Sreenivasan Paruthiyil, Hema R. Parmar, Vaishali Kerekatte, Gerald R. Cunha, Gary L. Firestone, Dale C. Leitman
Cancer research
2004

Studies indicate that estrogen receptor (ER) alpha mediates breast cancer-promoting effects of estrogens. The role of ERbeta in breast cancer is unknown. Elucidating the role of ERbeta in the… (More)

Immediate-early transcriptional regulation and rapid mRNA turnover of a putative serine/threonine protein kinase.

M. H. C. Webster, L. Goya, Gary L. Firestone
The Journal of biological chemistry
1993

Serine/threonine protein kinases are important regulators of diverse cellular processes including metabolism, proliferation, and differentiation. We have previously identified the cDNA for a 49-kDa… (More)

Cell cycle and hormonal control of nuclear-cytoplasmic localization of the serum- and glucocorticoid-inducible protein kinase, Sgk, in mammary tumor cells. A novel convergence point of…

Patricia Buse, Son Hai Tran, E A Luther, Phuong Phu, Gregory W. Aponte, Gary L. Firestone
The Journal of biological chemistry
1999

The serum- and glucocorticoid-inducible kinase (sgk) is a novel serine/threonine protein kinase that is transcriptionally regulated in rat mammary tumor cells by serum under proliferative conditions… (More)

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