Gary K. Ackers

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The OR control system of bacteriophage lambda. A physical-chemical model for gene regulation.

Madeline A Shea, Gary K. Ackers
Journal of molecular biology
1985

A quantitative model has been developed for processes in the bacteriophage lambda that control the switchover from lysogenic to lytic modes of growth. These processes include the interactions of cI… (More)

Quantitative model for gene regulation by lambda phage repressor.

Gary K. Ackers, Alexander Johnson, Madeline A Shea
Proceedings of the National Academy of Sciences…
1982

A statistical thermodynamic model has been developed to account for the cooperative interactions of the bacteriophage lambda repressor with the lambda right operator. The model incorporates a general… (More)

Molecular Exclusion and Restricted Diffusion Processes in Molecular-sieve Chromatography.

Gary K. Ackers
Biochemistry
1964

Coupled energetics of lambda cro repressor self-assembly and site-specific DNA operator binding I: analysis of cro dimerization from nanomolar to micromolar concentrations.

The cro repressor from bacteriophage lambda is an important and classical transcription regulatory protein that binds DNA operator sites as a dimer. Therefore, a complete understanding of gene… (More)

Site-specific enthalpic regulation of DNA transcription at bacteriophage lambda OR.

Binding of cI repressor to DNA fragments containing the three specific binding sites of the right operator (OR) of bacteriophage lambda was studied in vitro over the temperature range 5-37 degrees C… (More)

Molecular code for cooperativity in hemoglobin.

Gary K. Ackers, M L Doyle, D. Myers, Margaret A. Daugherty
Science
1992

Although tetrameric hemoglobin has been studied extensively as a prototype for understanding mechanisms of allosteric regulation, the functional and structural properties of its eight intermediate… (More)

λ Repressor and cro—components of an efficient molecular switch

Alexander Johnson, Anthony R. Poteete, Gail Lauer, Robert T. Sauer, Gary K. Ackers, Mark Ptashne
Nature
1981

In a lysogen, most genes of phage λ are repressed; in response to a transient induction signal, they are efficiently switched on. The switch, which consists in part of a tripartite operator to which… (More)

Analytical gel chromatography of proteins.

Gary K. Ackers
Advances in protein chemistry
1970

Calorimetric determination of the heat of oxygenation of human hemolgobin as a function of pH and the extent of reaction.

Donald H. Atha, Gary K. Ackers
Biochemistry
1974

Mutagenic dissection of hemoglobin cooperativity: effects of amino acid alteration on subunit assembly of oxy and deoxy tetramers.

George J. Turner, Frédéric Galactéros, +7 authors Gary K. Ackers
Proteins
1992

Free energies of oxygen-linked subunit assembly and cooperative interaction have been determined for 34 molecular species of human hemoglobin, which differ by amino acid alterations as a result of… (More)

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