Gary K. Ackers

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The OR control system of bacteriophage lambda. A physical-chemical model for gene regulation.

Madeline A Shea, Gary K. Ackers
Journal of molecular biology
1985

A quantitative model has been developed for processes in the bacteriophage lambda that control the switchover from lysogenic to lytic modes of growth. These processes include the interactions of cI… (More)

MOLECULAR EXCLUSION AND RESTRICTED DIFFUSION PROCESSES IN MOLECULAR-SIEVE CHROMATOGRAPHY.

Gary K. Ackers
Biochemistry
1964

Quantitative model for gene regulation by lambda phage repressor.

Gary K. Ackers, Alexander Johnson, Madeline A Shea
Proceedings of the National Academy of Sciences…
1982

A statistical thermodynamic model has been developed to account for the cooperative interactions of the bacteriophage lambda repressor with the lambda right operator. The model incorporates a general… (More)

Molecular code for cooperativity in hemoglobin.

Gary K. Ackers, Murray Doyle, D. Myers, Margaret A. Daugherty
Science
1992

Although tetrameric hemoglobin has been studied extensively as a prototype for understanding mechanisms of allosteric regulation, the functional and structural properties of its eight intermediate… (More)

Site-specific enthalpic regulation of DNA transcription at bacteriophage lambda OR.

Binding of cI repressor to DNA fragments containing the three specific binding sites of the right operator (OR) of bacteriophage lambda was studied in vitro over the temperature range 5-37 degrees C… (More)

λ Repressor and cro—components of an efficient molecular switch

Alexander Johnson, Anthony R. Poteete, Gail Lauer, Robert T. Sauer, Gary K. Ackers, Mark Ptashne
Nature
1981

In a lysogen, most genes of phage λ are repressed; in response to a transient induction signal, they are efficiently switched on. The switch, which consists in part of a tripartite operator to which… (More)

"Footprint" titrations yield valid thermodynamic isotherms.

M. Brenowitz, Donald F. Senear, Madeline A Shea, Gary K. Ackers
Proceedings of the National Academy of Sciences…
1986

A central issue in gene regulation is the mechanism, and biological function, of the cooperative binding of regulatory protein ligands to specific sites on DNA. To elucidate the physical-chemical… (More)

Energetics of subunit dimerization in bacteriophage lambda cI repressor: linkage to protons, temperature, and KCl.

A common feature of gene regulatory systems is the linkage between reversible protein oligomerization and DNA binding. Experimental dissection using temperature dependence of the subunit-subunit… (More)

Mutual effects of protons, NaCl, and oxygen on the dimer-tetramer assembly of human hemoglobin. The dimer Bohr effect.

Alex Chu, Gary K. Ackers
The Journal of biological chemistry
1981

The dimer-tetramer equilibrium constants of human oxyhemoglobin (4K2) and deoxyhemoglobin (0K2) have been determined at 21.5 degrees C as a function of pH and chloride concentration. In buffers… (More)

Effects of site-specific amino acid modification on protein interactions and biological function.

Gary K. Ackers, Franklin R Smith
Annual review of biochemistry
1985

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