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  • Mitra Boolell, Michael J Allen, +5 authors Clive Gingell
  • Medicine
  • International journal of impotence research
  • 1996 (First Published: 1 June 1996)
  • Sildenafil (Viagra, UK-92,480) is a novel oral agent under development for the treatment of penile erectile dysfunction. Erection is dependent on nitric oxide and its second messenger, cyclicContinue Reading
  • Donald J. Nichols, Gary J. Muirhead, Jane A Harness
  • Medicine
  • British journal of clinical pharmacology
  • 2002 (First Published: 6 March 2002)
  • AIMS To determine the absolute bioavailability, dose proportionality and the effects of food on the pharmacokinetics of single oral doses of sildenafil citrate. METHODS Three open-label, randomizedContinue Reading
  • Samantha Abel, Deborah Russell, Lyndsey A Whitlock, Caroline E Ridgway, Gary J. Muirhead
  • Medicine
  • British journal of clinical pharmacology
  • 2008 (First Published: 1 April 2008)
  • AIMS To assess the effect of maraviroc on the pharmacokinetics of midazolam, a sensitive probe CYP3A4 substrate; lamivudine/zidovudine, a combination of nucleoside reverse transcriptase inhibitorsContinue Reading
  • Gary J. Muirhead, Keith David Wilner, Wayne A. Colburn, Gertrude Haug-Pihale, Bernhard Rouviex
  • Medicine
  • British journal of clinical pharmacology
  • 2002 (First Published: 6 March 2002)
  • AIMS To investigate the effects of age and renal and hepatic impairment on the pharmacokinetics, tolerability and safety of sildenafil (single 50-mg oral dose) and its major circulating N-desmethylContinue Reading
  • Don K. Walker, Samantha Abel, Pierre Comby, Gary J. Muirhead, Angus N. R. Nedderman, Dennis A. Smith
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological…
  • 2005 (First Published: 1 April 2005)
  • UK-427,857 (4, 4-difluoro-N-[(1S)-3-[exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl]cyclohexanecarboxamide) is a novel CCR5 antagonist undergoingContinue Reading