Gary J. Ray

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The performance of three quantitative NMR methods was compared in terms of short-term and long-term precision and accuracy, robustness, linear range, and general applicability. The Internal Reference method employs a reference material co-dissolved with sample; the External Reference method employs a reference material contained in a separate solution; and(More)
The development of an all-solid-state cw laser system for optical absorption measurements of the OH radical in the UV spectral range is described. The tunable output of a 1064-nm external-cavity diode laser is amplified by use of a Nd:doped, double-clad fiber amplifier. The amplified near-IR radiation is frequency doubled by a periodically poled lithium(More)
This article addresses the identification and quantification of the chemical species resulting in resonances at 2.17 and 2.25 ppm in the (1)H nuclear magnetic resonance (NMR) spectrum of pharmaceutical-grade heparin sodium. The NMR signals in question were first confirmed to arise from chemical moieties covalently attached to the heparin molecule through(More)
Fucoidans are complex sulfated polysaccharides extracted from brown algae. Depending on the concentration, they have been shown to stimulate and inhibit blood coagulation in vitro. Promotion of coagulation is mediated by blocking tissue factor pathway inhibitor (TFPI). We screened fucoidan extracts from four brown algae species in vitro with respect to(More)
The relative donor properties of the three carbonyl groups of chlorophyll a have been studied theoretically by a series of ab initio molecular fragment, floating spherical Gaussian orbital, self-consistent field calculations on ethyl chlorophyllide a and experimentally through a 13C magnetic resonance study on chlorophyll a. The approximate ground state(More)
Native polysialic acid (natPSA) is a high-molecular-weight glycan composed of repeat units of α-(2 → 8) linked N-acetylneuraminic acid (Neu5Ac). Mild periodate oxidation of PSA selectively targets the end sialic acid ring containing three adjacent alcohols generating a putative aldehyde, which can be used, after attachment of a linker molecule, for terminal(More)
Use of an interline transfer CCD camera for the acquisition of broadband coherent anti-Stokes Raman-scattering (CARS) spectra is demonstrated. The interline transfer CCD has alternating columns of imaging and storage pixels that allow one to acquire two successive images by shifting the first image in the storage pixels and immediately acquiring the second(More)
Freezing of commonly used parenteral products to increase pharmaceutical stability for cost-saving purposes is a common practice in patient care. However, frozen meropenem, a model drug, in saline has a shelf life of less than a month due to the low glass transition temperature (Tg'): below -40°C. When meropenem is formulated with the(More)