Gary J Calton

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Ten years have elapsed since our last review article on the toxicology of venomous pelagic coelenterates was published (Burnett and Calton, 1977). Investigation on important medusae and the chemistry of their nematocyst venoms have been expanding. The venomous jellyfish discussed here include the Portuguese man-o'war, (Physalia physalis), the sea nettle(More)
To determine a reliable first aid topical remedy for jellyfish stings, we investigated several commonly available preparations to determine their ability to prevent nematocyst rupture from sea nettle (Chrysaora quinquecirrha) and Portuguese man-of-war (Physalia physalis) tentacles. The application of a baking soda slurry was a good inhibitor of nematocyst(More)
Jellyfish venoms are complex mixtures of polypeptides and enzymes pathogenic to man by means of their toxic or antigenic properties. With newer technology, more therapeutic agents will become available to treat the various envenomation syndromes caused by these animals. It will therefore be necessary to make an accurate diagnosis of the type of reaction the(More)
Flow cytometric separation of Physalia physalis nematocysts resulted in isolation of the two previously reported sizes of organelles measuring 10.6 and 23.5 nm in diameter. The venom of the smaller nematocysts, which are present in greater abundance, was lethal in vitro to chick embryonic cardiocytes at doses of 0.6 microgram protein/culture, whereas 20(More)
The sera of patients envenomated by the sea nettle (Chrysaora quinquecirrha) or the Portuguese man-o'war (Physalia physalis) were investigated for immune specific and cross-reacting antibodies. Crude or partially purified (SP-Sephadex column chromatography) nematocyst venom was used as antigen in an enzyme-linked immunosorbent assay (ELISA) designed to(More)
A protein lethal to mice was isolated from the sea nettle (Chrysaora quinquecirrha) mesenteric tentacle nematocysts by immunochromatography. The partially purified protein was also toxic to spontaneously beating cultural chick cardiocytes but was not hemolytic to rat erythrocytes. On sodium dodecyl sulfate polyacrylamide gels, the mesenteric protein(More)
A randomized double-blind trial to evaluate the safety of a novel recombinant virus, ICP10deltaPK, for reduction or prevention of recurrent herpes simplex virus type 2 (HSV-2) infection was carried out in public hospitals in Mexico City. Persons having a minimum of 5 documented herpetic recurrences in the previous year were randomized for vaccination.(More)