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The effect of dietary tyrosine and phenylalanine on survival of adult female C57BL/6 x DBA/2 F, mice bearing i.p. slow-growing, moderately pigmented and fast-growing, highly pig-mented B16 melanoma tumors was studied alone and in com bination with carbidopa-levodopa methyl ester chemotherapy. These studies tested three different diets: a natural product(More)
The effects of a combined dietary restriction of tyrosine and phenylalanine on metastasis were investigated with the use of 3 rodent tumor cell lines: B16-bladder 6 (BL6) melanoma inoculated into (C57BL/6 X DBA/2)F1 mice, Lewis lung (3LL) carcinoma inoculated into C57BL/6 mice, and RT7-4bs hepatocarcinoma inoculated into BD-IV rats. When examined for(More)
We report here the single and combined antitumor activity on B16 melanoma in female C57BL/6 X DBA/2F1 mice bearing s.c. tumors of sodium ascorbate, carbidopa-levodopa methyl ester, and dietary phenylalanine and tyrosine deficiency. Groups of 15 mice were fed continuously one of three test diets both with and without sodium ascorbate (30 mg/ml) in the(More)
Natural killer (NK) cell activity of spleen cells from female C57BL/6 mice receiving 10% w/v alcohol solution for 4 weeks was studied in mice fed a nutritionally complete crystalline amino-acid diet and in mice fed diets moderately deficient in (i) tyrosine and phenylalanine or (ii) methionine. Natural killer cell activity was determined in a 4-hr cytolytic(More)
Alcohol is a known suppressant to the immune system, and alcoholics frequently have impaired humoral and cell-mediated immunity. Several studies indicate that alcohol modulates natural killer (NK) cell activity. NK cells provide important defense against certain infectious diseases, spontaneously arising tumors and, in particular, to blood-borne(More)
Optimal NK cell development and activation as well as cytolytic activity involves IL-2R beta signals that also up-regulate expression of the pore-forming effector molecule perforin. Although the Jak/Stat pathway and specifically Stat5 transcription factors are required to promote many of the respective downstream events, the role of additional signaling(More)
The 14-3-3 epsilon protein was identified as one of the caspase-3 substrates by the modified yeast two-hybrid system. The cellular 14-3-3 epsilon protein was also cleaved in response to the treatment of apoptosis inducers in cultured mammalian cells. Asp238 of the 14-3-3 epsilon protein was determined as the site of cleavage by caspase-3. The affinity of(More)
Effects of 4-week food restriction and ethanol consumption on natural killer (NK) cell activity and carcass composition were evaluated. Female, C57BL/6 mice given water (H2O) or ethanol (20% w/v, ETOH) ad libitum were placed in one of three dietary groups: unrestricted (UNR), moderately restricted (MR, 2.2 g/day), or severely restricted (SR, 1.8 g/day).(More)
This study examined the mechanism underlying the increase of peripheral memory phenotype T cells that occurs during chronic alcohol consumption in mice. Female C57BL/6 mice were given 20% (w/v) alcohol in the drinking water for 2 weeks to 6 months. Chronic alcohol consumption significantly induced peripheral T cell lymphopenia; up-regulated expression of(More)