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- L. Müller, Y Kikuchi, +4 authors David J Tweats
- Mutation research
- 1999
The International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) has convened an expert working group which consisted of the authors of… (More)
- Byron E. Butterworth, Jamie Ashby, +4 authors G. Williams
- Mutation research
- 1987
The in vivo rat hepatocyte DNA-repair assay is a valuable tool in assessing the genotoxic activity of chemical agents. An advantage of the system is that it reflects the complex patterns of uptake,… (More)
- Roy K. Hom, Simeon G Bowers, +20 authors Irene Griswold-Prenner
- Bioorganic & medicinal chemistry letters
- 2010
From high throughput screening, we discovered compound 1, the prototype for a series of disubstituted thiophene inhibitors of JNK which is selective towards closely related MAP kinases p38 and Erk2.… (More)
- Detlev Branscheid, Sabine Krysa, +5 authors I. Vogt-Moykopf
- European journal of cardio-thoracic surgery…
- 1992
Surgery forms part of a combined oncological concept in the management of pulmonary metastases. The following questions are relevant for its role: Does survival depend on the type of primary tumor?… (More)
- H. Bauer, Wolfgang Stelzhammer, +4 authors István Krizbai
- Experimental cell research
- 1999
The expression of occludin, an integral plasma membrane protein specifically located at tight junctions, was studied in various epithelial and nonepithelial tissues by means of RT-PCR, Western… (More)
- Dr. A. Minovi, Gary D Probst, Stefan Dazert
- HNO
- 2009
Die Otosklerose kann viral bedingt sein und tritt in 25–50% der Fälle familiär gehäuft auf. Typisch ist eine ein- oder (bis zu 80%) beidseitige progressive Mittelohrschwerhörigkeit im jungen… (More)
- Gary D Probst, Simeon G Bowers, +27 authors Irene Griswold-Prenner
- Bioorganic & medicinal chemistry letters
- 2011
In this Letter, we describe the discovery of selective JNK2 and JNK3 inhibitors, such as 10, that routinely exhibit >10-fold selectivity over JNK1 and >1000-fold selectivity over related MAPKs, p38α… (More)
- Birgit Simon-Nobbe, Gary D Probst, +6 authors Michael Breitenbach
- The Journal of allergy and clinical immunology
- 2000
BACKGROUND
Cladosporium herbarum and Alternaria alternata are two of the most prominent fungal species inducing type I allergy. Previously, we have demonstrated that enolase (Cla h 6) is the second… (More)
- Byron E. Butterworth, Jamie Ashby, +4 authors G. Williams
- Mutation research
- 1987
The in vitro rat-hepatocyte DNA-repair assay is a valuable tool in assessing the genotoxic activity of chemical agents. An advantage of the assay is that the target cells themselves are metabolically… (More)
- Simeon G Bowers, Anh P Truong, +20 authors Irene Griswold-Prenner
- Bioorganic & medicinal chemistry letters
- 2011
The SAR of a series of tri-substituted thiophene JNK3 inhibitors is described. By optimizing both the N-aryl acetamide region of the inhibitor and the 4-position of the thiophene we obtained single… (More)