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■ This article presents an overview of the theoretical and practical issues associated with the development, analysis, and application of detection algorithms to exploit hyperspectral imaging data. We focus on techniques that exploit spectral information exclusively to make decisions regarding the type of each pixel—target or nontarget—on a pixel-by-pixel(More)
Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease. LRRK2 is a multifunctional protein affecting many cellular processes and has been described to bind microtubules. Defective microtubule-based axonal transport is hypothesized to contribute to Parkinson's disease, but whether LRRK2 mutations affect this(More)
■ Spectral imaging for remote sensing of terrestrial features and objects arose as an alternative to high-spatial-resolution, large-aperture satellite imaging systems. Early applications of spectral imaging were oriented toward ground-cover classification, mineral exploration, and agricultural assessment, employing a small number of carefully chosen(More)
Characterization of the joint (among wavebands) probability density function (pdf) of hyperspectral imaging (HSI) data is crucial for several applications, including the design of constant false alarm rate (CFAR) detectors and statistical classifiers. HSI data are vector (or equivalently multivariate) data in a vector space with dimension equal to the(More)
Real-time detection and identification of man-made objects or materials (" targets ") from airborne platforms using hyper-spectral sensors are of great interest for civilian and military applications. Over the past several years, different algorithms for the detection of targets with known spectral signature have been developed. Most of these algorithms(More)
In this paper, we introduce a set of taxonomies that hierarchically organize and specify algorithms associated with hyperspectral unmixing. Our motivation is to collectively organize and relate algorithms in order to assess the current state-of-the-art in the field and to facilitate objective comparisons between methods. The hyperspectral sensing community(More)
BACKGROUND Atherosclerosis is an inflammatory process that develops in individuals with known risk factors that include hypertension and hyperlipidaemia, influenced by diet. However, the interplay between diet, inflammatory mechanisms and vascular risk factors requires further research. We hypothesised that interleukin-1 (IL-1) signaling in the vessel wall(More)
Neutrophil lifespan and function are regulated by hypoxia via components of the hypoxia inducible factor (HIF)/von Hippel Lindau/hydroxylase pathway, including specific roles for HIF-1α and prolyl hydroxylase-3. HIF-2α has both distinct and overlapping biological roles with HIF-1α and has not previously been studied in the context of neutrophil biology. We(More)