Gary A. Rogers

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The deleterious effects of prolonged sleep deprivation on behavior and cognition are a concern in modern society. Persons at risk for impaired performance and health-related issues resulting from prolonged sleep loss would benefit from agents capable of reducing these detrimental effects at the time they are sleep deprived. Agents capable of improving(More)
Restoration of neuronal viability and synaptic plasticity through increased trophic support is widely regarded as a potential therapy for the cognitive declines that characterize aging. Previous studies have shown that in the hippocampal CA1 basal dendritic field deficits in the stabilization of long-term potentiation (LTP) are evident by middle age. The(More)
CX516 (BDP-12) and CX546, two first-generation benzamide-type AMPA receptor modulators, were compared with regard to their influence on AMPA receptor-mediated currents, autaptic responses in cultured hippocampal neurons, hippocampal excitatory postsynaptic currents, synaptic field potentials, and agonist binding. The two drugs exhibited comparable potencies(More)
Restoration of neuronal viability and synaptic plasticity through increased trophic support is widely regarded as a potential therapy for the cognitive declines that characterize aging. Previous studies have shown that in the hippocampal CA1 basal dendritic field deficits in the stabilization of long term potentiation (LTP) are evident by middle age. The(More)
The various mechanisms by which a neighboring imidazolyl nitrogen base (both neutral and anionic) or the conjugate acid imidazolium cation may participate in the hydrolysis of an acetyl ester of a weakly basic or strongly basic phenol have been evaluated (pH 0-13). For this purpose 0-acetyl esters of 2 4 2 ’ and 4‘-hydroxypheny1)imidazoles were prepared(More)
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