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Phosphate (Pi) reabsorption in renal proximal tubules involves Na+/Pi cotransport across the brush border membrane; its transport rate is influenced by the Na(+)-coupled transport of other solutes as well as by pH. In the present study, we have expressed a cloned rat renal brush border membrane Na+/Pi cotransporter (NaPi-2) in Xenopus laevis oocytes and(More)
Dopamine, a major neurotransmitter in the mammalian nervous system, exerts its physiological effects through receptors of the G-protein-coupled receptor superfamily. Two major classes of dopamine receptor, D1 and D2, are distinguishable by both biochemical and pharmacological criteria. D1 receptors activate adenylyl cyclase, whereas the D2 class of(More)
Pore progress: Oxford Nanopore's modified nanopore can distinguish between the four standard DNA nucleotides and methylated cytosine. The aim is to use an endonuclease (green) to feed the nucleotides to the pore one by one. (Photo: iemedia solutions.) Coming soon to a doctor's surgery near you? Hopes placed on the sequencing of 'the' human genome and the(More)
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