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We describe noninvasive techniques to optimize reflectometry measurements, particularly retinal densitometry, which measures the photopigment density difference. With these techniques unwanted scattered light is greatly reduced, and the retina is visualized during measurements. Thus results may be compared for each retinal location, and visible artifacts(More)
Two functional mitochondrial populations with different sedimentation rates (S) were obtained from homogenates of canine myocardium by rate zonal centrifugation using an iso-osmotic Ficoll gradient. To ascertain the origin of these populations, the left ventricular wall of normal myocardium was divided into subepicardial (outer one-third), intermediate(More)
PURPOSE Excess morbidity and mortality due to asthma, aggravated by demonstrably poor patient self-management practices, suggest the need for formal patient education programs. Individual and group asthma education programs were developed and evaluated to determine their cognitive, behavioral, and clinical effects. PATIENTS AND METHODS We compared changes(More)
We have designed a recording ophthalmoscope which requires substantially less light than conventional ophthalmoscopes or fundus cameras. A laser beam of <100-microW total power provides the flying spot on the subject's retina, allowing an inversion of the usual division of the pupil: only the central half-millimeter is needed for illumination, and the(More)
The scanning laser ophthalmoscope (SLO) system has been modified to permit direct retinal perimetry. A movable pinhole in a retinal conjugate plane furnishes a mapping stimulus whose retinal locus is directly observable on a video image of the fundus. Scotoma maps in patients with macular disease and physiologic scotomata associated with normal optic discs(More)
The scanning laser ophthalmoscope (SLO) provides a high-quality television image of the retina using less than 1/1000 of the light required for conventional indirect ophthalmoscopy. The SLO employs a new ophthalmoscopic principle in which a dim laser beam scans across the fundus, and light is collected only from one retinal point at a time. Since the(More)