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BACKGROUND The terrorist bombings in London on July 7, 2005, produced the largest mass casualty event in the UK since World War 2. The aim of this study was to analyse the prehospital and in-hospital response to the incident and identify system processes that optimise resource use and reduce critical mortality. METHODS This study was a retrospective(More)
OBJECTIVE The main hypothesis was that subtle vitamin B12 deficiencies occur more commonly in senile dementia of Alzheimer type (SDAT) that in healthy elderly individuals, and may be revealed by elevated total serum homocysteine (tHcy). A subsidiary hypothesis was that such deficiencies would be nutritionally independent as determined by retinol binding(More)
BACKGROUND Plasma homocysteine is elevated in Alzheimer's disease, but little is known regarding levels of related aminothiols in the disease. We therefore determined total plasma homocysteine, cysteine, and glutathione levels in patients and control subjects and investigated their relationship with cognitive scores. METHODS We performed a prospective,(More)
Moderately elevated total serum homocysteine is associated with an increased risk of atherothrombotic vascular events. Accordingly, serum homocysteine is increased in patients with vascular dementia but is also increased in clinically diagnosed and histologically confirmed AD. It is generally considered that homocysteine potentiates endothelial and neuronal(More)
OBJECTIVE To identify reliable predictors of outcome in comatose patients after cardiac arrest using a single routine EEG and standardized interpretation according to the terminology proposed by the American Clinical Neurophysiology Society. METHODS In this cohort study, 4 EEG specialists, blinded to outcome, evaluated prospectively recorded EEGs in the(More)
Barrett's esophagus is an increasingly common disease that is strongly associated with reflux of stomach acid and usually a hiatus hernia, and it strongly predisposes to esophageal adenocarcinoma (EAC), a tumor with a very poor prognosis. We report the first genome-wide association study on Barrett's esophagus, comprising 1,852 UK cases and 5,172 UK(More)
AIM To develop and initially validate a multi-dimensional questionnaire to measure cravings for amphetamine (speed). DESIGN, SETTING AND PARTICIPANTS The design of the Desires for Speed Questionnaire (DSQ) was based on the Desires for Alcohol Questionnaire and was administered to 174 amphetamine users. Exploratory factor analyses were carried out on the(More)
We construct secret-key encryption (SKE) schemes that are secure against related-key attacks and in the presence of key-dependent messages (RKA-KDM secure). We emphasize that RKA-KDM security is not merely the conjunction of individual security properties, but covers attacks in which ciphertexts of key-dependent messages under related keys are available.(More)
Results Context Investigated KDM Security in the context of Hybrid Encryption: § Present a generic composition theorem for adaptive, KDM-secure hybrid encryption in the Random Oracle model. § Proof method incorporates non-standard techniques that could be applicable in a wider context. Key-Dependent Message (KDM) Security involves an environment where the(More)