Gareth S. Rees

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Interleukin (IL)-6 has been proposed to mediate several sickness responses, including brain-mediated neuroendocrine, temperature, and behavioral changes. However, the exact mechanisms and sites of action of IL-6 are still poorly understood. In the present study, we describe the effects of central administration of species-homologous recombinant rat IL-6(More)
Adenovirus-mediated gene transfer into the brain is associated with significant inflammation and activation of anti-vector and anti-transgene immune responses that curtail the gene delivery of adenoviruses and therapeutic efficacy. Elucidating the molecular mediators of inflammatory and immune responses to adenoviruses injected into the brain should allow(More)
The classification of image regions of interest in an image is an important area of research. Generally most investigations concentrate on the optimi-sation of the constituent parts of the system without regard to the overall performance. This work takes a system centred approach. Using a novel multi-class receiver operating characteristic, which also(More)
Now including comments from prominent researchers in the field of computer and machine vision. Abstract This document presents a design methodology the aim of which is to provide a framework for constructing machine vision systems. Central to this approach is the use of empirical design techniques and in particular quantitative statistics. The methodology(More)
In order to investigate the relationship between chromosomal radiosensitivity and early-onset cancer, the G(2) chromosomal radiosensitivity assay was undertaken on a group of 23 Danish survivors of childhood and adolescent cancer, a control group comprising their partners and a group of 38 of their offspring. In addition, the previously reported in-house(More)
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