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We have exploited the complementary arrangement of afferents in a coronal slice (300-400 microm) of the rat olfactory tubercle (OT) maintained in vitro to investigate transmission in two separate synaptic pathways. We recorded extracellular responses within the OT dense cell layer in slices and stimulated either the outermost layer to activate primary(More)
BACKGROUND Mental capacity is central to legal and ethical debates on the use of compulsion in psychiatry. AIMS To describe the clinical epidemiology of mental incapacity in patients with psychiatric disorders, including interrater reliability of assessments, frequency in the psychiatric population and associations of mental incapacity. METHOD(More)
We tested a phenomenological hypothesis about theoretical and practical rationality in people with schizophrenia. This hypothesis states that in schizophrenia there is an enhancement of theoretical rationality. Our case-control experiment supported this hypothesis. Philosophical models of rationality that prioritise theoretical over practical rationality(More)
BACKGROUND Is the nature of decision-making capacity (DMC) for treatment significantly different in medical and psychiatric patients? AIMS To compare the abilities relevant to DMC for treatment in medical and psychiatric patients who are able to communicate a treatment choice. METHOD A secondary analysis of two cross-sectional studies of consecutive(More)
BACKGROUND Mental capacity is now a core part of UK mental health law and clinicians will increasingly be expected to assess it. Because it is a legal concept there is a need to clarify associations with variables that clinicians are more familiar with, especially insight. METHOD In this cross-sectional study we recruited consecutive psychiatric(More)
BACKGROUND Mental capacity is an emerging ethical legal concept in psychiatric settings but its relation to clinical parameters remains uncertain. We sought to investigate the associations of regaining capacity to make treatment decisions following approximately 1 month of in-patient psychiatric treatment. METHOD We followed up 115 consecutive patients(More)
OBJECTIVE To shed light on the difficulties faced by relatives, friends, and colleagues in interpreting signs of suicidality and deciding whether and how to intervene. DESIGN Qualitative study of completed suicides, based on in-depth interviews with multiple informants. SETTING London, southwest England, and south Wales. PARTICIPANTS 31 lay informants(More)
BACKGROUND Psychiatric disorders can pose problems in the assessment of decision-making capacity (DMC). This is so particularly where psychopathology is seen as the extreme end of a dimension that includes normality. Depression is an example of such a psychiatric disorder. Four abilities (understanding, appreciating, reasoning and ability to express a(More)
BACKGROUND In England and Wales mental health services need to take account of the Mental Capacity Act 2005 and the Mental Health Act 1983. The overlap between these two causes dilemmas for clinicians. AIMS To describe the frequency and characteristics of patients who fall into two potentially anomalous groups: those who are not detained but lack mental(More)