Gareth R. Jones

Jennifer M Jakobi3
Kaitlyn P Roland3
Olga Theou3
Jennifer M. Jakobi3
Trevor R Norman2
3Jennifer M Jakobi
3Kaitlyn P Roland
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Functional neuroimaging studies in patients with obsessive-compulsive disorder (OCD) suggest there is a hyperactivation of the anterior cingulate cortex (ACC) during provocation of symptoms and conflict-inhibition tasks. Since dopamine, acting through D(1) receptors is suggested to modulate ACC activity, we hypothesised that there would be an altered D(1)(More)
  • Olga Theou, Liza Stathokostas, Kaitlyn P. Roland, Jennifer M. Jakobi, Christopher Patterson, Anthony A. Vandervoort +1 other
  • 2011
This systematic review examines the effectiveness of current exercise interventions for the management of frailty. Eight electronic databases were searched for randomized controlled trials that identified their participants as "frail" either in the title, abstract, and/or text and included exercise as an independent component of the intervention. Three of(More)
BACKGROUND Obsessive-compulsive disorder (OCD) is a chronic anxiety disorder of unknown aetiology. Psychopharmacological studies have suggested a role for the neurotransmitter serotonin however further evidence for serotonin in the aetiology of OCD is conflicted. The authors used positron emission tomography (PET) to examine the binding of the dopamine D(1)(More)
The purpose of this study was to develop a brief physical activity interview for older adults (Phone-FITT) and evaluate its test-retest reliability and validity. Summary scores were derived for household, recreational, and total PA. Reliability was evaluated in a convenience sample from a fall-prevention study (N = 43, 79.4 +/- 2.9 years, 51% male), and(More)
BACKGROUND Single-item physical activity questions provide a quick approximation of physical activity levels. While recall questionnaires provide a more detailed picture of an individual's level of physical activity, single-item questions may be more appropriate in certain situations. The aim of this study was to evaluate two single-item physical activity(More)
Males and females may exhibit diverse expressions of Parkinson's disease (PD) as a result of biological and social differences. In general, a higher incidence of PD is found among males (RR=1.5) compared to females. However, rigidity, postural instability and levodopa-induced dyskinesia are more prevalent in females with PD. These fluctuations affect motor(More)
Although the knee adduction moment during gait is a valid and reliable proxy for the dynamic load on the medial compartment of the knee, it represents exposure to loading during one stride only. In contrast, a measure that incorporates both the nature and frequency of loading throughout daily activities might provide additional insight into the effects of(More)
Females with Parkinson's disease (PD) are at increased risk for frailty, yet are often excluded from frailty studies. Daily electromyography (EMG) recordings of muscle activity can dissociate stages of frailty and indicate functional decline in non-neurological conditions. The purpose of this investigation was to determine whether muscle activity can be(More)
The rapid advancement of electromyography (EMG) technology facilitates measurement of muscle activity outside the laboratory during daily life. The purpose of this study was to determine whether bursts in EMG recorded over a typical 8-hour day differed between young and old males and females. Muscle activity was recorded from biceps brachii, triceps(More)
SCOPE Daily bilateral electromyography (EMG) recordings reveal muscle activation patterns implicated in asymmetric Parkinson's disease (PD)-related functional decline. Also, daily EMG recordings reveal sex-differences in muscle activity that give rise to unique PD presentation in males and females. PURPOSE Quantify handgrip strength and daily muscle(More)