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Image segmentation and delineation is at the heart of modern radiotherapy, where the aim is to deliver as high a radiation dose as possible to a cancerous target whilst sparing the surrounding healthy tissues. This, of course, requires that a radiation oncologist dictates both where the tumour and any nearby critical organs are located. As well as in(More)
Nerve cell bodies projecting to the ovary were visualized in dorsal root ganglia (DRG) and paravertebral ganglia after application of the retrograde tracer Fluoro-gold to the superior ovarian and plexus nerves. The location of fluorescent cells in sections of ganglia was recorded and subsequently nicotinamide adenine dinucleotide phosphate(More)
Any single valued function over a sphere or cylinder can be parameterised in terms of the spherical or cylindrical coordinate systems respectively. An organ structure created during medical image segmentation can be written as such a function if the shape is polar (i.e. star shaped), the polar radial distance from a reference point inside the structure to(More)
It is well known that observer variability during delineation and organ motion relative to set-up markers heavily contribute to errors accrued during the radiotherapy treatment planning process. Margins are placed around the delineated tumour volumes to account for this uncertainty, inevitably resulting in healthy tissue exposure with the associated(More)
The use of time-of-treatment imaging is increasingly commonplace in radiotherapy, with cone beam CT (CBCT) the primary modality. To make full use of this technology, the tumour target and critical organs need to be segmented from the image volumes. CBCT images unfortunately often suffer from poor contrast and significant image artefacts compared with the(More)
Bilateral section of either the sensory or motor branch of the pelvic nerve or pudendal nerve was performed in rats on days 8-10 of pregnancy, and the effects on delivery were observed. Bilateral resection of the sensory branch of the pelvic nerve reduced the number of live pups per litter, and increased the number of stillbirths and the number of fetuses(More)
Rats were subjected to right side dorsal rhizotomy of spinal nerves T12-L2 and ipsi- or contralateral unilateral ovariectomy at estrus (day 1). Estrous cycles were recorded daily, and on day 15 the remaining ovary was removed and weighed. Antral follicles were counted in representative day 1 and day 15 ovaries. Dorsal rhizotomy did not affect estrous cycles(More)
The hypothesis that endogenous opioids might have a role in mediating the suppressive effects of nicotine on serum LH concentrations in rats was investigated. Naltrexone treatment prevented the inhibitory effect of high doses of nicotine on serum LH concentrations. Nicotine treatment also prevented the stimulatory effect of naltrexone on serum LH(More)