Gareth Price

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Binding of the cytoskeletal protein vinculin to talin is one of a number of interactions involved in linking F-actin to cell-matrix junctions. To identify the talin binding domain in vinculin, we expressed the NH2-terminal region of the molecule encoded by two closely similar, but distinct vinculin cDNAs, using an in vitro transcription translation system.(More)
Image segmentation and delineation is at the heart of modern radiotherapy, where the aim is to deliver as high a radiation dose as possible to a cancerous target whilst sparing the surrounding healthy tissues. This, of course, requires that a radiation oncologist dictates both where the tumour and any nearby critical organs are located. As well as in(More)
The acoustic emission from collapsing cavitation bubbles generated using ultrasound of 20 kHz and 515 kHz frequencies in water has been measured and correlated with sonoluminescence and hydroxyl radical production to yield further information on the frequency dependence of sonochemical reactions. A reasonable correlation was found, and the results suggest(More)
This version is made available in accordance with publisher policies. Please cite only the published version using the reference above. Abstract An ultrasonic dental descaling instrument has been characterised using sonochemical techniques. Mapping the emission from luminol solution revealed the distribution of cavitation produced in water around the tips.(More)
A large body of evidence has implicated mitochondria in control of cell death, where key apoptotic mechanisms involve change in mitochondrial membrane permeability and depolarisation of mitochondrial membrane potential (∆ψm). Assessment of ∆ψm is traditionally conducted using the lipophilic cation JC-1 on the flow cytometer or by fluorescent microscopy.(More)
Stimulated Raman scattering microscopy was used to assess the permeation of topically applied drugs and formulation excipients into porcine skin. This chemically selective technique generates high-resolution 3D images, from which semi-quantitative information may be elucidated. Ibuprofen, applied as a close-to-saturated solution in propylene glycol, was(More)
It is well known that observer variability during delineation and organ motion relative to set-up markers heavily contribute to errors accrued during the radiotherapy treatment planning process. Margins are placed around the delineated tumour volumes to account for this uncertainty, inevitably resulting in healthy tissue exposure with the associated(More)