Gareth M C Lema

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Upon activation by agonist, the type A gamma-aminobutyric acid receptor (GABAR) 'gates', allowing chloride ions to permeate membranes and produce fast inhibition of neurons. There is no consensus kinetic model for the GABAR gating mechanism. We expressed human alpha(1)beta(1)gamma(2S) GABARs in HEK 293 cells and recorded single channel currents in the(More)
PURPOSE To identify prognostic indicators of postoperative visual acuity and retinal detachment (RD) in open globe injuries. METHODS Retrospective review of 50 adult open globe injuries between September 2011 and March 2014. Hierarchical multivariable regression was used to evaluate relationships among injury characteristics, postoperative visual acuity,(More)
The inflammation, so conspicuous in cases of respiratory distress, pneumonia, and asthma, is associated with an airway invasion of plasma proteins and a release into the airway lumen of phospholipase A2 (PLA2). This enzyme catalyzes hydrolysis of surfactant phospholipids, the most abundant and important of which is dipalmitoylphosphatidylcholine (DPPC). Its(More)
Patients with cystic fibrosis are severely affected by an infection with Pseudomonas aeruginosa, a microbe known to synthesize phospholipase C. This study was designed to determine whether that enzyme would affect the function of pulmonary surfactant phospholipids. Mucoid and nonmucoid strains of P. aeruginosa, freshly obtained from patients with cystic(More)
Pulmonary surfactant maintains patency of narrow conducting airways. An inflammation, with a leakage of plasma proteins into the airway lumen, causes surfactant to lose some of this ability. Will a lowering of temperature aggravate the deteriorating effect of an inflammation? Calf lung surfactant extract (CLSE) with proteins added was studied with a(More)
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