Gareth J Rowlands

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Rat neostriatal slices exhibited a Ca2+-dependent release of endogenous glutamate when depolarized by elevated K+. This evoked release was reduced by 30% in tissue from animals subjected to fronto-parietal lesions 3 weeks previously. These results support the proposal that glutamate is the transmitter of the cortico-striatal pathway.
We have developed a general strategy for the synthesis of 2,5-syn disubstituted pyrrolidines that is based on the multi-faceted reactivity of the sulfone moiety and a 5-endo-trig cyclisation. This methodology was applied to the synthesis of indolizidine alkaloid monomorine I. Two factors were key to the success of this endeavour; the first was the choice of(More)
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