Rat neostriatal slices exhibited a Ca2+-dependent release of endogenous glutamate when depolarized by elevated K+. This evoked release was reduced by 30% in tissue from animals subjected to fronto-parietal lesions 3 weeks previously. These results support the proposal that glutamate is the transmitter of the cortico-striatal pathway.
This paper describes a simple route to enantiomerically enriched [2.2]paracyclophane-4-thiol via the stereospecific introduction of a chiral sulfoxide to the [2.2]paracyclophane skeleton. The first synthesis of an enantiomerically enriched planar chiral benzothiazole is also reported.
We have developed a general strategy for the synthesis of 2,5-syn disubstituted pyrrolidines that is based on the multi-faceted reactivity of the sulfone moiety and a 5-endo-trig cyclisation. This methodology was applied to the synthesis of indolizidine alkaloid monomorine I. Two factors were key to the success of this endeavour; the first was the choice of… (More)