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We report on a test to assess the dynamic brain function at high temporal resolution using magnetoencephalography (MEG). The essence of the test is the measurement of the dynamic synchronous neural interactions, an essential aspect of the brain function. MEG signals were recorded from 248 axial gradiometers while 142 human subjects fixated a spot of light(More)
OBJECTIVE To evaluate benefits for postnatal women of two psychologically informed interventions by health visitors. DESIGN Prospective cluster trial randomised by general practice, with 18 month follow-up. SETTING 101 general practices in Trent, England. PARTICIPANTS 2749 women allocated to intervention, 1335 to control. INTERVENTION Health(More)
OBJECTIVE To determine the efficacy of IV immunoglobulin (IVIg) given patients with untreated chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). METHODS A randomized, double-blind, multicenter, investigator-initiated study compared IVIg (Aventis Behring LLC, King of Prussia, PA) with placebo (5% albumin). On days 1, 2, and 21, IVIg (1 g/kg)(More)
We report five patients with pure motor neuropathy characterized by multifocal weakness, muscle atrophy that was sometimes profound, cramps, and fasciculations with relatively preserved reflexes. The clinical picture led to an initial diagnosis of motor neuron disease in all cases, but nerve conduction studies revealed multifocal conduction block confined(More)
PURPOSE The aim of this study was to describe the development, introduction, implementation, and current models of critical care outreach services. MATERIALS AND METHODS We conducted a national postal survey of National Health Service acute care hospitals in England that routinely provide care for level 1 patients (n = 239). RESULTS Completed(More)
Maximal voluntary isometric contraction (MVIC) is becoming widely used for monitoring disease progression in amyotrophic lateral sclerosis (ALS). We evaluated the variability of MVIC in a large multicenter (29 sites) drug trial in ALS. Intra- and interrater variability were assessed twice during the 19-month study. Intrarater reliability increased from the(More)
OBJECTIVE To determine the effect of different sites and local skin temperature on thermal thresholds. METHODS Cool and warm detection and cold and heat pain thresholds were compared in 46 normal volunteers at the thenar eminence (TE), dorsum of the hand (DH), volar surface of the wrist (VW) and dorsum of the foot (DF). RESULTS The hand is more(More)
We modified the World Federation of Neurology (WFN) diagnostic criteria for ALS to facilitate early diagnosis and used these criteria for enrollment of ALS patients in a clinical trial. The criteria developed required lower motor neuron (LMN) involvement in at least two limbs and upper motor neuron involvement in at least one region (bulbar, cervical, or(More)
OBJECTIVE To determine the effect of different sites and locally applied pressure on vibration thresholds. METHODS Vibration thresholds were compared in 47 normal volunteers at 3 sites of the index finger (pulp, dorsum of the middle phalanx and nail) and at two sites of the great toe (dorsum of the proximal phalanx and nail). The effect of local pressure(More)