Gareth J. Martin

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Investigations of the inhibition of the activity of xanthine oxidase in vitro have yielded a number of substances which have been reported to exert marked inhibitory actions at low concentrations. Among these are p-aminophenol in its oxidized form (l), pyrogallol (a), bromoacetophenone (3)) 6-pteridylaldehyde (4)) and 6-hydroxymethylpterin (5). An(More)
Site-specific natural isotope fractionation of hydrogen studied by deuterium NMR (SNIF-NMR) spectroscopy is a powerful source of information on hydrogen pathways occurring in biosyntheses in natural conditions. The potential of the carbon counterpart of this method has been investigated and compared. Three typical molecular species, ethanol, acetic acid,(More)
Intussusception, the telescoping of one segment of bowel onto an adjacent segment, is uncommon in adults in the United States. This is in contrast to intussusception in the tropics, where most cases occur in adults with GI infections. HIV-infected patients are at high risk for conditions that predispose to intussusception, namely tumors and infections of(More)
The transport of various organic anions via the pathway that mediates the exchange of urate or p-aminohippurate (PAH) for OH- or Cl- in dog renal microvillus membrane vesicles was investigated. The pH gradient-stimulated uptakes of tracer urate and PAH were significantly inhibited by 5 mM PAH, n-valerate, lactate, beta-hydroxybutyrate, pyruvate,(More)
In a previous communication (1) it was reported that certain vitamin I’ compounds exerted an inhibitory action on the breakdown of hyaluronic acid by testis hyaluronidase, as determined turbidimetrically. This action was manifested for the most part only when the compounds in question were combined with ascorbic acid, and only when their concentration was(More)