Gareth D Hughes

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In certain circumstances inference based on the likelihood function can be hindered by, for example, computational complexity; new applications of directional statistics to bioinformatics problems give many obvious examples. In such cases it is necessary to seek an alternative method of estimation. Two pseudolikelihoods, each based on conditional(More)
Strategies to augment anti-cancer immune responses have recently demonstrated therapeutic utility. To date clinical success has been achieved through targeting co-inhibitory checkpoints such as CTLA-4, PD-1, and PD-L1. However, approaches that target co-activatory pathways are also being actively being developed. Here we report that the novel TLR7-selective(More)
This review describes recent advances in the fabrication of electrochemical (bio)sensors based on screen-printing technology involving carbon materials and their application in biomedical, agri-food and environmental analyses. It will focus on the various strategies employed in the fabrication of screen-printed (bio)sensors, together with their performance(More)
Idiopathic Pulmonary Fibrosis (IPF) now has two licensed treatments available. Pirfenidone was the first drug to be licensed and approved for use, followed by nintedanib. We set out our real world experience with these agents in terms of their adverse events profile outside the restrictions of a clinical trial. We have demonstrated in the real world(More)
This project centers on a novel device that stores energy electrochemically in tanks like a flow battery, while the materials and chemistry are more akin to those of a solid-oxide fuel cell – hence the name " Solid Oxide Flow Battery " (SOFB). The SOFB is well suited for grid-scale energy storage because the energy storage capacity can be increased by(More)
This project centers on a novel device that stores energy electrochemically in tanks like a flow battery, while the materials and chemistry are more akin to those of a solid-oxide fuel cell – hence the name " Solid Oxide Flow Battery " (SOFB). The SOFB is well suited for grid-scale energy storage because the energy storage capacity can be increased by(More)