Gareth Christie

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The purpose of this report is to convey the findings of the DTI – funded International Technology Service Mission on North American Best Practice in Mobile Entertainment.The mission investigated a broad range of North American companies involved in the development of mobile content including mobile game developers and publishers, as well as mobile service(More)
Mice fed a diet containing 1% (w/w) 3-hydroxy-4(1H)-pyridone (DHP) developed goitre even with a diet high in iodine whereas mimosine (0.5% w/w) did not produce goitre even with a low-iodine diet. Thyroid enlargement was apparent (measured morphometrically) by the 7th week and was advanced by the 11th week. Histologically the goitre was hyperplastic in type.(More)
Mimosine, a plant amino acid which is toxic in mammals, was shown to be a potent inhibitor of incorporation of [3H]thymidine in mouse bone marrow cells in liquid culture (is greater than 70% inhibition at a concentration of 2 x 10(-4) M). To determine the parts of the molecule responsible for the inhibitory mechanism the effects of 13 chemically related(More)
Haematoporphyrin diacetate has been synthesized and purified. Following introduction into mice bearing squamous-cell carcinomas it was found to produce a fluorescence of the tumour tissue which was much stronger than that of the surrounding normal tissue. Haematoporphyrin diacetate was also shown to be the major active component of the impure compound known(More)
THE effects of dimethylnitrosamine (DMN) on the rabbit have been studied (15 mg./kg. body weight) produced severe liver necrosis and death within 24 1955). Rabbits fed diets containing low concentrations of DMN for 28 weeks did not show severe changes in the liver, although death resulted after the animals received DMN 50 p.p.m. during the last 8 weeks of(More)