Gareth Chelvanayagam

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The simultaneous substitution of pairs of buried amino acid side chains during divergent evolution has been examined in a set of protein families with known crystal structures. A weak signal is found that shows that amino acid pairs near in space in the folded structure preferentially undergo substitution in a compensatory way. Three different(More)
Two bona fide consensus predictions of secondary and tertiary structure in a protein family, made and announced before experimental structures were known, are evaluated in light of the subsequently determined experimental structures. The first, for phospho-beta-galactosidase, identified the core strands of an 8-fold alpha-beta barrel, and identified the(More)
The conservation of the overall fold after many amino The simultaneous substitution of pairs of buried amino acid acid substitutions also raises the possibility that amino acid side chains during divergent evolution has been examined in substitutions at one position in a polypeptide chain might be a set of protein families with known crystal structures. A(More)
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