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Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants.

• Dongwei Kang, Zengjun Fang, +15 authors Xinyong Liu
• Journal of medicinal chemistry
• 2017

This work follows on from our initial discovery of a series of piperidine-substituted thiophene[3,2-d]pyrimidine HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTI) ( J. Med. Chem. 2016 ,… (More)

Glyoxal-Urea-Formaldehyde Molecularly Imprinted Resin as Pipette Tip Solid-Phase Extraction Adsorbent for Selective Screening of Organochlorine Pesticides in Spinach.

• Chen Yang, Tianwei Lv, Hongyuan Yan, Gaochan Wu, Haonan Li
• Journal of agricultural and food chemistry
• 2015

A new kind of glyoxal-urea-formaldehyde molecularly imprinted resin (GUF-MIR) was synthesized by a glyoxal-urea-formaldehyde (GUF) gel imprinting method with 4,4'-dichlorobenzhydrol as a dummy… (More)

Further Exploring Solvent-Exposed Tolerant Regions of Allosteric Binding Pocket for Novel HIV-1 NNRTIs Discovery.

• Dongwei Kang, Zhao Wang, +17 authors Xinyong Liu
• ACS medicinal chemistry letters
• 2018

Based on the detailed analysis of the binding mode of diarylpyrimidines (DAPYs) with HIV-1 RT, we designed several subseries of novel NNRTIs, with the aim to probe biologically relevant chemical… (More)

Novel fused pyrimidine and isoquinoline derivatives as potent HIV-1 NNRTIs: a patent evaluation of WO2016105532A1, WO2016105534A1 and WO2016105564A1.

• Dongwei Kang, Zhipeng Huo, Gaochan Wu, Jiabao Xu, Peng Zhan, Xinyong Liu
• Expert opinion on therapeutic patents
• 2017

INTRODUCTION In the three patent applications, the impact of changing the pyrimidine core of the rilpivirine (RPV) to a variety of alternative fused cores was explored, culminating in the… (More)

Discovery of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the Tolerant Region I of NNIBP.

• Dongwei Kang, Xiao Ding, +11 authors Xinyong Liu
• ACS medicinal chemistry letters
• 2017

Our previous studies led us to conclude that thiophene[3,2-d]pyrimidine is a promising scaffold for diarylpyrimidine (DAPY)-type anti-HIV agents with potent activity against resistance-associated… (More)

Current insights into anti-HIV drug discovery and development: a review of recent patent literature (2014-2017).

• Xiaofang Zuo, Zhipeng Huo, +4 authors Peng Zhan
• Expert opinion on therapeutic patents
• 2018

INTRODUCTION To deal with the rapid emergence of drug resistance challenges, together with the difficulty to eradicate the virus, off-target effects and significant cumulative drug toxicities, it is… (More)

Discovery of novel diarylpyrimidines as potent HIV-1 NNRTIs by investigating the chemical space of a less explored "hydrophobic channel".

• Zhongxia Zhou, Tao Liu, +7 authors Xinyong Liu
• Organic & biomolecular chemistry
• 2018

A new series of diarylpyrimidines (DAPYs) were designed, synthesized and evaluated as novel HIV-1 NNRTIs to further explore the chemical space surrounding the "hydrophobic channel" of the NNRTI… (More)

Discovery of Novel Diarylpyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the "NNRTI Adjacent" Binding Site.

• Zhipeng Huo, Heng Zhang, +12 authors Xinyong Liu
• ACS medicinal chemistry letters
• 2018

A novel series of diarylpyrimidine derivatives, which could simultaneously occupy the classical NNRTIs binding pocket (NNIBP) and the newly reported "NNRTI Adjacent" binding site, were designed,… (More)

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