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Preventive effects of Laminaria japonica aqueous extract on the oxidative stress and xanthine oxidase activity in streptozotocin-induced diabetic rat liver.
TLDR
LJE significantly suppressed the increased activity of XO and type conversion of the xanthine dehydrogenase to XO in diabetic rat liver, suggesting that LJE would be of great value in preventing hyperglycemia in diabetes mellitus as a dietary supplement possibly, through its antioxidant activity.
ADAM15 targets MMP9 activity to promote lung cancer cell invasion.
TLDR
It is found that high expression of ADAM15 was associated with decreased overall survival (OS) and disease-free survival (DFS) in NSCLC patients and shRNA-mediated knockdown ofADAM15 attenuated cell migration and invasion, and a novel mechanism of ADam15 in promoting cancer cell invasion through directly targeting MMP9 activation is revealed.
GPR78 promotes lung cancer cell migration and metastasis by activation of Gαq-Rho GTPase pathway
TLDR
It is demonstrated that in vivo, the knockdown of GPR78 inhibited lung cancer cell metastasis and may serve as a potential drug target against metastatic human lung cancer.
Experimental study on magnetic drug targeting in treating cholangiocarcinoma based on internal magnetic fields
Objective: To evaluate the effect of magnetic nanoparticle containing 5-fluorouracil (5-FU) targeting in treating cholangiocarcinoma based on internal magnetic fields built inside the tumor. Methods:
Tubeimoside-1 suppresses breast cancer metastasis through downregulation of CXCR4 chemokine receptor expression
TLDR
Tubimoside-1 suppressed the CXCR4-mediated metastasis of breast cancer by inhibiting NF-κB binding activity and suppressed breast cancer metastasis in the metastatic model of nude mice.
Simultaneous blockage of epidermal growth factor receptor and cyclooxygenase-2 in a human xenotransplanted lung cancer model.
TLDR
Simultaneous blockage of the EGFR and COX-2 signal pathways exerted stronger growth effects in the human xenotransplanted lung cancer model than inhibition of either pathway alone.
Study of transfer t-PA gene to the goat fetal fibroblasts and nuclear transfer
TLDR
Goat fetal fibroblasts were transfered into mammary gland expressed vector pEBT t-PA gene by using lipofectamin to make nuclear transfer embryos, and the result showed that the morulae rate and blastocyst rate of fetal fibrablasts cells were higher than that offetal fibro Blasts cells.
Effect of the Combination of Acupuncture and Chinese Medicine in Treating Aphasla in Pstients of Acute Ischemic Stroke
TLDR
The clinical efficacy, improvement of spontaneous talk and repeat of the speech ability in observation group were significantly better than those in control group and in Chinese medicine syndromes and the symptoms of sounding organs, the combining therapy showed the tendency of better improvement.
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