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- Gerda Egger, Gangning Liang, Ana Aparicio, Peter A. Jones
- Nature
- 2004
Epigenetic mechanisms, which involve DNA and histone modifications, result in the heritable silencing of genes without a change in their coding sequence. The study of human disease has focused on… (More)
- Yoshimasa Saito, Gangning Liang, +4 authors Peter A. Jones
- Cancer cell
- 2006
Expression profiling of T24 cells revealed that 17 out of 313 human miRNAs were upregulated more than 3-fold by simultaneous treatment with the chromatin-modifying drugs 5-aza-2'-deoxycytidine and… (More)
- Keith D. Robertson, Eva Uzvolgyi, +4 authors Peter A. Jones
- Nucleic acids research
- 1999
DNA methylation in mammals is required for embryonic development, X chromosome inactivation and imprinting. Previous studies have shown that methylation patterns become abnormal in malignant cells… (More)
- Theresa K. Kelly, Yaping Liu, Fides D. Lay, Gangning Liang, Benjamin P. Berman, Peter A. Jones
- Genome research
- 2012
DNA methylation and nucleosome positioning work together to generate chromatin structures that regulate gene expression. Nucleosomes are typically mapped using nuclease digestion requiring… (More)
- Peter A. Jones, Gangning Liang
- Nature Reviews Genetics
- 2009
DNA methylation patterns are set up early in mammalian development and are then copied during the division of somatic cells. A long-established model for the maintenance of these patterns explains… (More)
- Tina Branscombe Miranda, Connie C Cortez, +5 authors Peter A. Jones
- Molecular cancer therapeutics
- 2009
DNA methylation, histone modifications, and nucleosomal occupancy collaborate to cause silencing of tumor-related genes in cancer. The development of drugs that target these processes is therefore… (More)
- David Roulois, Helen Loo Yau, +9 authors Daniel Diniz de Carvalho
- Cell
- 2015
DNA-demethylating agents have shown clinical anti-tumor efficacy via an unknown mechanism of action. Using a combination of experimental and bioinformatics analyses in colorectal cancer cells, we… (More)
- Erika M. Wolff, Yoshitomo Chihara, +7 authors Gangning Liang
- Cancer research
- 2010
Urothelial cancer (UC) develops along two different genetic pathways, resulting in noninvasive or invasive tumors. However, it is unknown whether there are also different epigenetic pathways in UC.… (More)
- Gerda Egger, Shinwu Jeong, +6 authors Gangning Liang
- Proceedings of the National Academy of Sciences…
- 2006
Previous studies have shown that DNA methyltransferase (Dnmt) 1 is required for maintenance of bulk DNA methylation and is essential for mouse development. However, somatic disruption of DNMT1 in the… (More)
- Jeffrey M. Friedman, Gangning Liang, +5 authors Peter A. Jones
- Cancer research
- 2009
The Polycomb Repressive Complex 2 (PRC2) mediates epigenetic gene silencing by trimethylating histone H3 lysine 27 (H3K27me3) and is known to aberrantly silence tumor suppressor genes in cancer.… (More)