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Pitch period is a key parameter in speech compression, synthesis and recognition. The AMDF is often used to determine this parameter. Due to the falling trend of the AMDF curve, however, it is easy to make the estimated pitch doubled or halved To correct these errors, the algoritlun has to increase its complexity. In this paper, we propose a new function,(More)
During human brain development, the cerebral cortex undergoes substantial folding, leading to its characteristic highly convoluted form. Folding is necessary to accommodate the expansion of the cerebral cortex; abnormal cortical folding is linked to various neurological disorders, including schizophrenia, epilepsy, autism, and mental retardation. Although(More)
By putting different chips on the same mask, shuttle mask (or multiple project wafer) provides an economical solution for low volume designs and design prototypes to share the rising mask cost. A challenging floorplanning problem is to optimally pack these chips according to objectives and constraints related to cost and manufacturability. In this paper, we(More)
BACKGROUND Age at onset of Huntington's disease (HD) is correlated with the size of the abnormal CAG repeat expansion in the HD gene; however, several studies have indicated that other genetic factors also contribute to the variability in HD age at onset. To identify modifier genes, we recently reported a whole-genome scan in a sample of 629 affected(More)
Redundant via insertion is a good solution to reduce the yield loss by via failure. However, the existing methods are all post-layout optimizations that insert redundant via after detailed routing. In this paper, we propose the first routing algorithm that considers feasibility of redundant via insertion in the detailed routing stage. Our routing problem is(More)
OBJECTIVE The cellular basis of cognitive abnormalities in preterm infants with periventricular leukomalacia (PVL) is uncertain. One important possibility is that damage to white matter and subplate neurons that are critical to the formation of the cerebral cortex occurs in conjunction with oligodendrocyte and axonal injury in PVL. We tested the hypothesis(More)
In this paper, we present the design and implementation of Smart Messages, a distributed computing platform for networks of embedded systems based on execution migration. A Smart Message (SM) is a user-defined distributed program which executes on nodes of interest, named by their properties, and uses an explicit lightweight migration to reach these nodes.(More)
BACKGROUND The PARK2 gene at 6q26 encodes parkin, whose inactivation is implicated in an early-onset autosomal recessive form of Parkinson disease (PD). OBJECTIVE To evaluate the influence of heterozygosity for parkin mutation on onset age in a sample of families with at least 2 PD-affected members. DESIGN Clinical and genetic study. SETTING Twenty(More)