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Blurring the line between software and hardware, reconfigurable devices strike a balance between the raw high speed of custom silicon and the post-fabrication flexibility of general-purpose processors. While this flexibility is a boon for embedded system developers, who can now rapidly prototype and deploy solutions with performance approaching custom(More)
Cancer is a highly heterogeneous disease in terms of the genetic profile and the response to therapeutics. An early identification of a genomic marker in drug discovery may help select patients that would respond to treatment in clinical trials. Here we suggest coupling compound screening with comparative genomic hybridization analysis of the model systems(More)
Apoptosis is a widely accepted component of the pathogenesis of Parkinson's disease (PD), a debilitating neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra. In this study, we investigated the neuroprotective effects of puerarin and possible mechanisms by which puerarin acts against MPP(+)-induced toxicity in rat(More)
Design space exploration during high-level synthesis is often conducted through ad hoc probing of the solution space using some scheduling algorithm. This is not only time consuming but also very dependent on designer's experience. We propose a novel design exploration method that exploits the duality of time- and resource-constrained scheduling problems.(More)
In this paper, an efficient method based on the discrete harmonic wavelet packet transform (DHWPT) is presented to classify surface electromyographic (SEMG) signals. After the relative energy of SEMG signals in each frequency band had been extracted by the DHWPT, a genetic algorithm was utilized to select appropriate features in order to reduce the feature(More)
To kill invading bacteria, neutrophils must interpret spatial cues, migrate and reach target sites. Although the initiation of chemotactic migration has been extensively studied, little is known about its termination. Here we found that two mitogen-activated protein kinases (MAPKs) had opposing roles in neutrophil trafficking. The extracellular(More)
Many types of embryos' bodyplans exhibit consistently oriented laterality of the heart, viscera, and brain. Errors of left-right patterning present an important class of human birth defects, and considerable controversy exists about the nature and evolutionary conservation of the molecular mechanisms that allow embryos to reliably orient the left-right(More)
A study of ventricular fibrillation and ventricular tachycardia was undertaken using multifractal analysis. By applying the method of direct determination of the f(alpha) singularity spectrum, the value of the area of the VF and VT singularity spectrum was calculated. The comparison between the results showed that the value of the area of the VF singularity(More)
Modern digital systems consist of a complex mix of computational resources, e.g. microprocessors, memory elements and reconfigurable logic. System partitioning – the division of application tasks onto the system resources – plays an important role for the optimization of the latency, area, power and other performance metrics. This paper presents a novel(More)
Many established cancer therapies involve DNA-damaging chemotherapy or radiotherapy. Gain of DNA repair capacity of the tumor represents a common mechanism used by cancer cells to survive DNA-damaging therapy. Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme that is activated by DNA damage and plays a critical role in base excision repair.(More)