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In this paper, a corner block list -- a new efficient topological representation for non-slicing floorplan is proposed with applications to VLSI floorplan and building block placement. Given a corner block list, it takes only linear time to construct the floorplan. Unlike the O-tree structure, which determines the exact floorplan based on given block sizes,(More)
In press ABSTRACT Significant climate anomalies persist through the summer (June-August) after El Nino dissipates in spring over the equatorial Pacific. They include the tropical Indian Ocean (TIO) sea surface temperature (SST) warming, increased tropical tropospheric temperature, an anomalous anticyclone over the subtropical Northwest Pacific, and(More)
Copper and iron metabolism intersect in mammals. Copper deficiency simultaneously leads to decreased iron levels in some tissues and iron deficiency anemia, whereas it results in iron overload in other tissues such as the intestine and liver. The copper requirement of the multicopper ferroxidases hephaestin and ceruloplasmin likely explains this link(More)
This paper investigates the global stability of virus dynamics model with Beddington–DeAngelis infection rate. By constructing Lyapunov functions, the global properties have been analysed. If the basic reproductive ratio of the virus is less than or equal to one, the uninfected steady state is globally asymptotically stable. If the basic reproductive ratio(More)
Regulation of the hematopoietic transcription factor PU.1 (Spi-1) plays a critical role in the development of white cells, and abnormal expression of PU.1 can lead to leukemia. We previously reported that the PU.1 promoter cannot induce expression of a reporter gene in vivo, and cell-type-specific expression of PU.1 in stable lines was conferred by a 3.4-kb(More)
The importance of the p53 protein in the cellular response to DNA damage is well known, but its function during steady-state hematopoiesis has not been established. We have defined a critical role of p53 in regulating hematopoietic stem cell quiescence, especially in promoting the enhanced quiescence seen in HSCs that lack the MEF/ELF4 transcription factor.(More)
El Niño induces a basin-wide increase in tropical Indian Ocean (tropical IO, TIO) sea surface temperature (SST) with a lag of one season. The North IO (NIO), in particular, displays a peculiar double-peak warming with the second peak larger in magnitude and persisting well through the summer. Motivated by recent studies suggesting the importance of the TIO(More)
Clinical evidence regarding the value of 18F-FDG PET for therapy responses assessment in breast cancer is increasing. The objective of this study is to evaluate the accuracy of 18F-FDG PET in predicting responses to neoadjuvant therapies with meta-analysis and explore its optimal regimen for clinical use. Articles in English language relating to the(More)
BACKGROUND AND PURPOSE Esophageal cancer is the third most common gastrointestinal malignancy with a poor long-term survival and high mortality. Surgical resection provides the only chance of cure. The tumor-node metastasis stage classification system is a strong prognostic parameter predicting the prognosis. We performed the present meta-analysis to(More)