Ganesh Venkataraman

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1 Introduction We introduce certain conventions and notations that will be used throughout this paper. For any graph G = (V, E) and any subset C ⊆ E of edges, let G\C denote the graph G = (V, E − C). (u → v) G denotes that there is a path from the vertex u to the vertex v in the graph G; ¬(u → v) G denotes that there is no such path. Let α(G, C) = {(u,v) |(More)
We present a fast and efficient combinatorial algorithm to simultaneously identify the candidate locations as well as the sizes of the buffers driving a clock mesh. Due to the high redundancy, a mesh architecture offers high tolerance towards variation in the clock skew. However, such a redundancy comes at the expense of mesh wire length and power(More)
To participate as co-receptor in growth factor signaling, heparan sulfate must have specific structural features. Recent studies show that when the levels of 6-O-sulfation of heparan sulfate are diminished by the activity of extracellular heparan sulfate 6-O-endosulfatases (Sulfs), fibroblast growth factor 2-, heparin binding epidermal growth factor-, and(More)
Clock skew is becoming increasingly difficult to control due to variations. Link based non-tree clock distribution is a cost-effective technique for reducing clock skew variations. However, previous works based on this technique were limited to unbuffered clock networks and neglected spatial correlations in the experimental validation. In this work, we(More)
Heparan sulfate proteoglycans (HSPGs) play a key role in shaping the tumor microenvironment by presenting growth factors, cytokines, and other soluble factors that are critical for host cell recruitment and activation, as well as promoting tumor progression, metastasis, and survival. M402 is a rationally engineered, non-cytotoxic heparan sulfate (HS)(More)
In comparison with genomics and proteomics, the advancement of glycomics has faced unique challenges in the pursuit of developing analytical and biochemical tools and biological readouts to investigate glycan structure-function relationships. Glycans are more diverse in terms of chemical structure and information density than are DNA and proteins. This(More)
Power/ground noise is a major source of VLSI circuit timing variations. This work aims to reduce clock network induced power noise by assigning different signal polarities (opposite switchings) to clock buffers in an existing buffered clock tree. Three assignment algorithms are proposed: (1) partitioning, (2) 2-coloring on minimum spanning tree and (3)(More)
The activity of several angiogenic factors, like ®bro-blast growth factors (FGF), is modulated by heparin-like glycosaminoglycans (HLGAGs), which are acidic polysaccharides present in the extracellular matrix and at the cell surface. FGF binds to HLGAG in the matrix, where it is sequestered in a protected and inactive form, and at the cell surface, where it(More)
The clock distribution network is a key component on any synchronous VLSI design. As technology moves into the nanometer era, innovative clocking techniques are required to solve the power dissipation and variability issues. Rotary clocking is a novel technique which employs unterminated rings formed by differential transmission lines to save power and(More)
The synthesis of clock network in the presence of process variation is becoming a vital design issue towards the performance of digital circuits. In this paper, we propose a clock tree design algorithm which is driven by the tolerance towards process variations. We consider tolerance to process variation in various stages of clock tree synthesis which(More)