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Phosphoinositide 3-kinases (PI3K) regulate immune activation via their roles in signal transduction of multiple classes of receptors. Here, we examined the effect of genetic inactivation of the hemopoietic cell-restricted PI3K isoform p110delta on systemic cytokine and chemokine responses and allergic airway inflammation. We found that type 2 cytokine(More)
RATIONALE Interleukin (IL)-13 plays a pivotal role in the pathogenesis of allergic asthma. Passive administration of its monoclonal antibody or soluble receptor to block overproduced IL-13 has been proven to be effective in controlling airway allergic responses in animal models, but these approaches have disadvantages of short half-lives, high costs, and(More)
Alveolarization is impaired in rats treated with dexamethasone (Dex) on postnatal days 4-13, but concomitant treatment with all-trans retinoic acid (RA) increases alveolar number. To determine whether morphological changes induced by Dex and/or RA predict changes in lung function at 1 mo, we assessed resting breathing parameters, dynamic compliance,(More)
In this paper, a loop-back test scheme for RF transceivers using optimized periodic bit streams is presented. In this approach, optimized periodic bitstreams modulated at baseband are sent through RF transmit subsystem, and the transmitter output is looped back into the receiver using the proposed test architecture. The corresponding test response is(More)
In this paper, a novel algorithm has been proposed to measure system specifications of an integrated transmitter, which capture the non-linearities of the system-under-test. The measurement of these specifications is important, as these determine the amount of " interference " created by the transmitting system in adjacent channels while transmitting data(More)
Changes in the normal rhythm of a human heart may result in different cardiac arrhythmias, which may be immediately causes irreparable damage to the heart sustained over long periods of time. The ability to automatically identify arrhythmias from ECG recordings is important for clinical diagnosis and treatment. In this paper we proposed an Artificial Neural(More)