Ganesh Shahane

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The human b 2-adrenergic receptor (b 2 AR), a member of the G-protein coupled receptor (GPCR) family, is expressed in bronchial smooth muscle cells. Upon activation by agonists, b 2 AR causes bronchodilation and relief in asthma patients. The N-terminal polymorphism of b 2 AR at the 16 th position, Arg16Gly, has warranted a lot of attention since it is(More)
The serotonin1A receptor belongs to the superfamily of G protein-coupled receptors (GPCRs) and is a potential drug target in neuropsychiatric disorders. The receptor has been shown to require membrane cholesterol for its organization, dynamics and function. Although recent work suggests a close interaction of cholesterol with the receptor, the structural(More)
Computer aided simulation is an integral part of science and engineering technology. Simulation provides verification of the basic theory, understanding the basic principles, greater attention to the theoretical limitations, and application of logical analysis to solve real-world problems. The objective of this paper is to discuss simulation software(More)
Functional and conformational transitions of the Sophora japonica seed lectin (SJL) were studied in detail using bioinformatics and biophysical tools. Homology model of the lectin displayed all the characteristics of the legume lectin monomer and the experimental observations correlated well with the structural information. In silico studies were performed(More)
The human β2-adrenergic receptor (β2AR), a member of the G-protein coupled receptor (GPCR) family, is expressed in bronchial smooth muscle cells. Upon activation by agonists, β2AR causes bronchodilation and relief in asthma patients. The N-terminal polymorphism of β2AR at the 16th position, Arg16Gly, has warranted a lot of attention since it is linked to(More)
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