Ganesh B Rao

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Medulloblastomas are malignant brain tumors that arise in the cerebella of children. The presumed cells-of-origin are undifferentiated precursors of granule neurons that occupy the external granule layer (EGL) of the developing cerebellum. The overexpression of proteins that normally stimulate proliferation of neural progenitor cells may initiate(More)
Absence seizures are one of the features of idiopathic generalised epilepsy (IGE) and occur as component of many different syndromes. They are commonly associated with various clinical features such as mild clonic components, change in postural tone, automatisms and autonomic phenomena. Childhood absence epilepsy (CAE) is the prototype IGE with typical(More)
INTRODUCTION Histopathological images have rich structural information, are multi-channel in nature and contain meaningful pathological information at various scales. Sophisticated image analysis tools that can automatically extract discriminative information from the histopathology image slides for diagnosis remain an area of significant research activity.(More)
Clinical methods of detecting diabetic peripheral neuropathy (DPN) are not objective and reproducible. We therefore evaluated if SUDOSCAN, a new method developed to provide a quick, non-invasive and quantitative assessment of sudomotor function can reliably screen for DPN. 70 subjects (45 with type 1 diabetes and 25 healthy volunteers [HV]) underwent(More)
BACKGROUND Surgery for tumors in eloquent brain faces immense challenges when attempting to maximize resection and avoid neurological deficits. OBJECTIVE In order to give the surgeon real-time atlas-based anatomic information linked to the patient's anatomy, we developed a software-based interface between deformable anatomic templates (DATs) and an(More)
BACKGROUND We wanted to study the role of functional MRI (fMRI) in preventing neurological injury in awake craniotomy patients as this has not been previously studied. OBJECTIVES To examine the role of fMRI as an intraoperative adjunct during awake craniotomy procedures. METHODS Preoperative fMRI was carried out routinely in 214 patients undergoing(More)
A large unmet need exists for cost-effective, widely available antineoplastic immunotherapeutic agents with a robust translational potential. MicroRNAs (miRNAs) that regulate tumor-mediated immunosuppression or immune checkpoints can induce robust therapeutic immune responses, indicating that miRNAs may ultimately become part of the portfolio of anticancer(More)
BACKGROUND Awake craniotomy with cortical stimulation is the standard for language mapping in patients with tumors near or within the language cortex. Reliable identification of the speech cortex is difficult, however, and adjunctive pre- and intraoperative techniques have inconsistent reliability. OBJECTIVES We describe a technique based on direct(More)
Lipoma arborescens (LA) is a rare non-neoplastic intra-articular lesion that most commonly affects the knee joint, especially the suprapatellar bursa. It rarely affects the elbow joint. There are a few reports of involvement of the bicipital radial bursa. We report a case of LA, with characteristic MRI features, affecting the elbow joint in a young male.
The majority of glioblastomas have aberrant receptor tyrosine kinase (RTK)/RAS/phosphoinositide 3 kinase (PI3K) signaling pathways and malignant glioma cells are thought to be addicted to these signaling pathways for their survival and proliferation. However, recent studies suggest that monotherapies or inappropriate combination therapies using the(More)