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Intratumoural lymphatics in benign and malignant soft tissue tumours

• Gandham Mahendra, Karolina Kliskey, K. Williams, Kevin Hollowood, D. Jackson, Nicholas Anthony Athanasou
• Virchows Archiv
• 2008

Soft tissue sarcomas do not generally metastasise via lymphatics, and the presence or absence of lymphatic vessels within sarcomas and benign soft tissue tumours is not known. In this study, we… (More)

Antiangiogenic cancer gene therapy by adeno-associated virus 2-mediated stable expression of the soluble FMS-like tyrosine kinase-1 receptor

• Gandham Mahendra, S. Srinivas Kumar, +9 authors Selvarangan Ponnazhagan
• Cancer Gene Therapy
• 2005

Antiangiogenic gene transfer has the potential to be more efficacious than protein-based therapies or pharmacotherapies for the control of solid tumor growth, invasion and metastasis. For a sustained… (More)

Osteogenic differentiation of recombinant adeno-associated virus 2-transduced murine mesenchymal stem cells and development of an immunocompetent mouse model for ex vivo osteoporosis gene therapy.

• Sanjay Kumar, Gandham Mahendra, Tim R Nagy, Selvarangan Ponnazhagan
• Human gene therapy
• 2004

Gene therapy for osteopenic conditions including osteoporosis is a potential alternative to pharmacotherapy for cost effectiveness, long-term viability, and the ability to enhance bone mass by… (More)

Adeno-associated virus type 2-mediated transduction of human monocyte-derived dendritic cells: implications for ex vivo immunotherapy.

• Selvarangan Ponnazhagan, Gandham Mahendra, David Curiel, Denise R. Shaw
• Journal of virology
• 2001

Dendritic cells (DCs) are pivotal antigen-presenting cells for regulating immune responses. A major focus of contemporary vaccine research is the genetic modification of DCs to express antigens or… (More)

Determination of osteoprogenitor-specific promoter activity in mouse mesenchymal stem cells by recombinant adeno-associated virus transduction.

• Sanjay Kumar, Gandham Mahendra, Selvarangan Ponnazhagan
• Biochimica et biophysica acta
• 2005

Towards utilizing gene-targeted, repopulating mesenchymal stem cells (MSC) to increase osteogenesis, we evaluated the expression of bone-specific promoters during MSC differentiation. Multi-lineage… (More)

Age-related and steroid induced changes in the histones of the quail liver.

• Gandham Mahendra, Mandakini Kanungo
• Archives of gerontology and geriatrics
• 2000

Histones were extracted from the liver of young, adult and old Japanese quails. Both linker and core histones were found to vary with age. An extra band, H3X, was found between H2A and H4. Its level… (More)

Conjugate-based targeting of recombinant adeno-associated virus type 2 vectors by using avidin-linked ligands.

• Selvarangan Ponnazhagan, Gandham Mahendra, S. Srinivas Kumar, John A. Thompson, Mark Castillas
• Journal of virology
• 2002

The development of targeted vectors, capable of tissue-specific transduction, remains one of the important aspects of vector modification for gene therapy applications. Recombinant adeno-associated… (More)

Augmentation of antitumor activity of a recombinant adeno-associated virus carcinoembryonic antigen vaccine with plasmid adjuvant.

• Selvarangan Ponnazhagan, Gandham Mahendra, +8 authors Pierre L Triozzi
• Human gene therapy
• 2004

Recombinant adeno-associated virus 2 (rAAV) vectors have been successfully used for sustained expression of therapeutic genes. The potential of using rAAV as a cancer vaccine vector and the impact of… (More)

Smooth muscle actin expression in primary bone tumours

• Francesca K E Hemingway, Tsuyoshi Kashima, +4 authors Nicholas Anthony Athanasou
• Virchows Archiv
• 2012

Alpha isoform of smooth muscle actin (SMA) expression has been reported in giant cell tumour of bone (GCTB) and other benign and malignant bone tumours, but the pattern of SMA expression and the… (More)

Implementation of Split Radix Algorithm for 12 - Point FFT & IFFT

• P. Malyadri, D. Jayanayudu, Gandham Mahendra

Discrete Fourier transform (DFT) is widespread used in many fields of science and engineering. DFT is implemented with efficient algorithms categorized as Fast Fourier Transform. A fast algorithm is… (More)

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