Gan Zhou

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PURPOSE To assess the impacts of erythromycin on the pharmacokinetics of voriconazole and its association with CYP2C19 genotypes in healthy Chinese male subjects. METHODS A single-center, open, crossover clinical study with two treatment phases was carried out. Eighteen healthy male volunteers, including 6 CYP2C19 homozygous extensive metabolizers (EMs,(More)
Cyber-physical systems such as autonomous spacecraft, power plants and automotive systems become more vulnerable to unanticipated failures as their complexity increases. Accurate tracking of system dynamics and fault diagnosis are essential. This paper presents an efficient state estimation method for dynamic systems modeled as concurrent probabilistic(More)
The dynamic nature of hybrid systems involves discrete switching behavior between several operating modes and continuous plant dynamics governed by continuous models in each mode. State estimation is a important class of approaches for online monitoring and diagnosis of hybrid systems, which relies on the estimation of unknown variables using a filtering(More)
Fault diagnosis is crucial for guaranteeing safe, reliable and efficient operation of modern engineering systems. These systems are typically hybrid. They combine continuous plant dynamics described by continuous-state variables and discrete switching behavior between several operating modes. This paper presents an integrated approach for online tracking(More)
AIM To investigate the drug interactions between ilaprazole, a new proton pump inhibitor, and clarithromycin following ilaprazole, clarithromycin and amoxicillin combination therapy. METHODS Twelve healthy Chinese volunteers were recruited in a randomized, open-label, 3-period crossover study. All subjects were administered ilaprazole (5 mg),(More)
Reconfigurable processors, like the Field Programmable Gate Arrays (FPGA's), open new computational paradigms where the processor is able to tailor its internal structure to better. implement a given application. A typical FPGA consists of an array of configurable logic blocks and a mesh of interconnections fully programmable by the user to perform a given(More)
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