Galina Nikolova

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BACKGROUND/AIMS The most important parameter determining the outcome of colorectal cancer (CRC) is the presence of metastases, which occur in 45-50% of all cases. The balance between proliferation and apoptosis is a key factor for tumor growth, and thus--for metastasis. Evaluation of markers for proliferation and apoptosis could therefore be helpful in(More)
This study was carried out to investigate possible protection effect of 1-ethyl-3-[4-(2,2,6,6-tetramethylpiperidine-1-oxyl)]-1-nitrosourea (SLENU), synthesized in our laboratory, against oxidative liver injuries induced in mice treated by antitumor drugs: doxorubicin (DOX), bleomycin (BLM), or gamma irradiation (R). Specifically, alterations in some(More)
The increasing data provides enough evidences confirming the involvement of free radicals and other reactive oxygen species (ROS) superoxide radical ( . O 2 − ), nitric oxide (NO . ), hydrogen peroxide (H2O2) and hydroxyl radicals ( . OH) in a number of physiological and pathological processes. Imbalance between levels of ROS resulting in the body and the(More)
Gamma radiation generates free radicals in biological system by inducing cellular water radiolysis. If not neutralised, free radicals oxidise vital bio-macromolecules causing structural and functional impairment and contribute to cell death. In present study, free radical scavenging activities of a novel bacterial secondary metabolite, N-acetyl tryptophan(More)
Levodopa (L-dopa) is a "gold standard" and most effective symptomatic agent in the Parkinson's disease (PD) treatment. The several treatments have been developed in an attempt to improve PD treatment, but most patients were still levodopa dependent. The issue of toxicity was raised in vitro studies, and suggests that L-dopa can be toxic to dopaminergic(More)
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