Galina M Khramova

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Preliminary non-thermal activation of cold-sensitive TRPM8 ion channel facilitates initiation of the heat-defense responses in homoiothermal animals by decreasing temperature threshold of the vasodilatory response. TRPM8 activation leads to earlier heat-initiated increase in oxygen consumption, but reduces its magnitude. Warming inhibits the lipolytic(More)
The existence of co-transmitters of the sympathetic nervous system norepinephrine (NE) and ATP implies variations in the neuromodulator mechanisms of physiological processes. The role of ATP, as a transmitter of the peripheral part of sympathetic nervous system in the formation of thermoregulatory response is not clear. Whether ATP modulates any parameters(More)
Involvement of various areas of the body surface in heat emission response to warming is characterized by a certain succession. The first response preceding the deep body temperature rise is dilation of ear skin vessels. Then, an increase in deep body temperature is counterbalanced by vascular reaction in the tail region, which plays the leading role in(More)
Animal experiments were performed to study the effects of activation of cold- and menthol-sensitive TRPM8 receptors by menthol on thermoregulatory parameters in thermoneutral conditions and on cooling. Total oxygen consumption was measured, along with expiration of carbon dioxide, the respiratory coefficient, the skin vessel constriction reaction, and(More)
Mechanisms of maintenance of temperature homeostasis in warm and under effect of cold were studied in mice of AKR line and of its coherent line AKR.CBA-D13Mit76 with the changed gene i16 encoding the gp130 receptor via which IL-6 performs its action. Under thermoneutral conditions and under action of cold, there were recorded temperature parameters, total(More)
Activation of central 5-HT(3) receptors by the selective agonist m-CPBG (1-(3-chlorophenyl)biguanide hydrochloride, 40 nM i.c.v.) produced stronger hypothermic effect in mice than activation of 5-HT(1A) receptors by their agonist 8-OH-DPAT (8-hydroxy-2-(di-n-propilamino)tetralin) injected by the same route at an equimolar dose. The hypothermic effect of(More)
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