Galen M. Pieper

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OBJECTIVE Previous studies suggest a role of superoxide anion radicals (.O2-) in impaired endothelium-dependent relaxation of diabetic blood vessels; however, the role of secondary reactive oxygen species remains unclear. In the present study, we investigated a role of various potential reactive oxygen species in diabetic endothelial dysfunction. METHODS(More)
Background. TGF-b and oxidative stress are known mediators of renal injury. However, the precise mechanisms by which TGF-b and oxidative stress may be involved in the development of nephrotoxicity are not known. We examined whether anti-TGF-b antibody limits nephrotoxicity produced by tacrolimus (TAC) and whether this altered genes that regulate oxidative(More)
Nitric oxide (NO) donors such as sodium nitroprusside (SNP, 0.01-1 micrograms) or 3-morpholino-sydnonimine (SIN-1, 0.1-10 micrograms) administered intracerebroventricularly (i.c.v) produced a dose-dependent potentiation of beta-endorphin-induced antinociception assessed by the tail-flick test in ICR mice. The same i.c.v. treatment with SNP or SIN-1 did not(More)
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