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BACKGROUND Ezrin is a member of the ezrin, radixin, and moesin family that provides a functional link between the plasma membrane and the cortical actin cytoskeleton. A correlation between ezrin overexpression and aggressive cancer behavior has been recently reported in various tumor types. However, its roles in the mechanisms underlying progression of(More)
Multi-agent systems can be viewed as systems in which large numbers of agents process jobs by interacting with each other. We have been applying such a multi-agent system to electronic commerce (EC) on the Internet since December 1997. Since the server on the system has to host thousands of agents that process jobs in a disorderly manner, the mechanism for(More)
There are many studies on ABS and several frameworks for ABS have already been published. However, there are few frameworks that can enable agent-based simulation using large numbers of agents. We have been developing a Java-based platform for Massive Agent-Based Simulation (MABS) called "Zillions of Agents-based Simulation Environment" or ZASE. The purpose(More)
INTRODUCTION Recombinant human bone morphogenetic protein-2 (rh-BMP2) has osteoinductive properties. The sequence of osteogenesis induced by rh-BMP2 in a rat calvarial bone defect model was evaluated histologically. MATERIAL AND METHODS Atelopeptide type I collagen was selected as the carrier matrix for rh-BMP2. This collagen was mixed with 50 microg of(More)
The dietary components responsible for the development of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) remain unclear. Wistar rats were divided into four groups based on their diet: a low soybean-oil diet, a low cow-fat diet, a high soybean-oil diet, and a high cow-fat diet. First, we evaluated the bile acid composition of the bile juice in(More)
Osteoblasts and adipocytes are believed to share a common progenitor. Peroxisome proliferator-activated receptor gamma (PPARgamma) plays a key role in the switching of these two cell lineages. Here, we demonstrated the differentiation of ES cells into an osteoblastic lineage using siRNA against PPARgamma without the addition of any osteogenic factors. We(More)
p62/SQSTM1 (sequestosome1) has never been evaluated in oral epithelium. In order to clarify the role of p62/SQSTM1 in carcinogenesis in oral epithelium, both p62/SQSTM1 and Nrf2 were immunohistochemically evaluated in 54 carcinomas and 14 low grade dysplasias. p62/SQSTM1 knockdowns were also designed in oral cancer cells, and we analyzed the Nrf2 pathway,(More)
Laser diffraction (LD) has been recognized as a method for estimating particle size distribution. Here, a recently developed quantitative LD (qLD) system, which is an LD method with extensive deconvolution analysis, was employed for the quantitative assessment of protein particles sizes, especially aimed at the quantification of 0.2-10 μm diameter(More)
Several epidemiological cohort studies have suggested that duodeno-gastroesophageal reflux per se induces Barrett's esophagus leading to increased risk of the development of esophageal adenocarcinoma (EAC). However, the exact causative factors behind EAC remain unclear. Recently, we designed a new duodenal contents reflux model which retained normal stomach(More)