Gail E. Handelmann

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Previous studies suggest that during nerve regeneration apoE acts as a lipid transport protein that assists in the rapid initial extension of axons and then in their myelination. To determine whether apoE and/or apoE-containing lipoproteins can modulate axon growth, we assessed their effect on the out-growth of neurites from neurons in mixed cultures of(More)
Abstract In vitro assays using crude synaptosomal membrane preparations from the cortex and cytosolic fraction of hippocampus have shown that in the brain, steroids can bind to the intracellular corticosteroid receptors as well as to the membrane-bound GABA-receptor complex. Corticosteroid, deoxycorticosterone and spironolactone bound with higher affinity(More)
Peptides which act as neurotransmitters or neuromodulators in the adult nervous system exert influences on brain development. Altering the levels of neuropeptide to which a developing animal is exposed produces a wide variety of physiological and behavioral effects which are apparent in adulthood. Many of the developmental effects involve neural systems in(More)
Phencyclidine (PCP) produces many profound effects in the central nervous system. PCP has numerous behavioral and neurochemical effects such as inhibiting the uptake and facilitating the release of dopamine, serotonin, and norepinephrine. PCP also interacts with sigma, mu opioid, muscarinic, and nicotinic receptors. However, the psychotomimetic effects(More)
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