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Manganese (Mn) is an essential mineral that is found in varying amounts in aerosols or dust. Exposure to atmospheric Mn at high concentration is a risk factor in humans that can manifest as neuronal degeneration resembling Parkinson's disease (PD). Since the underlying mechanism of Mn and dopamine (DA) interaction-induced cell death remains unclear, here,(More)
In the past few decades, computer science has driven innovation across a variety of academic fields and become a robust part of democratic participation and the labor economy. Today's youth are surrounded with applications of these new technologies that impact how they access and produce information and communicate with friends, family, and educators. Yet,(More)
The use of tungsten as a replacement for lead and depleted uranium in munitions began in the mid 1990's. Recent reports demonstrate tungsten solubilizes in soil and can migrate into drinking water supplies and therefore is a potential health risk to humans. This study evaluated the reproductive and neurobehavioral effects of sodium tungstate in(More)
  • Deborah Seehorn, Stephen Carey, Brian Fuschetto, Irene Lee, Daniel Moix, Dianne O 'grady-Cunniff +32 others
  • 2011
copies of portions of this work for personal or classroom use is granted without fee provided that the copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than ACM must be honored. Abstracting with credit is(More)
Olfactory transport of represents an important mechanism for direct delivery of certain metals to the central nervous system (CNS). The objective of this study was to determine whether inhaled tungsten (W) undergoes olfactory uptake and transport to the rat brain. Male, 16-week-old, Sprague-Dawley rats underwent a single, 90-min, nose-only exposure to a(More)
The central nervous system (CNS) appears to be the critical target of manganese (Mn), and neurotoxicity has been the focus of most of the health effects of manganese. In brain, the mechanism underlying the Mn-induced cell death is not clear. We have previously demonstrated that NFkappabeta induction and the activation of nitric oxide synthase through(More)
This session will present the research findings to date from an 18-month study commissioned by the ACM in partnership with the National Science Foundation, Google, Computer Science Teachers Association, Microsoft, and the National Center for Woman and Information Technology that started in July, 2012, and invite an open discussion about them. The study(More)
  • K Reed, A Hubacek, T P Bonn, J Burt, L C Holden, N Stringer +41 others
  • 2013
Anticipating and managing future trade-offs and complementarities between ecosystem services. ABSTRACT. This paper shows how, with the aid of computer models developed in close collaboration with decision makers and other stakeholders, it is possible to quantify and map how policy decisions are likely to affect multiple ecosystem services in future. In this(More)
Our previous studies found that experimental infection of BALB/c mice with the Gram-positive bacterium Nocardia asteroides induced a parkinsonian-type syndrome with levodopa-responsive movement abnormalities, loss of nigrostriatal dopaminergic neurons, depletion of striatal dopamine, and intraneuronal inclusions in the substantia nigra (SN) with an(More)