Learn More
The International Mouse Phenotyping Consortium (IMPC) web portal (http://www.mousephenotype.org) provides the biomedical community with a unified point of access to mutant mice and rich collection of related emerging and existing mouse phenotype data. IMPC mouse clinics worldwide follow rigorous highly structured and standardized protocols for the(More)
High-throughput phenotyping is a cornerstone of numerous functional genomics projects. In recent years, imaging screens have become increasingly important in understanding gene-phenotype relationships in studies of cells, tissues and whole organisms. Three-dimensional (3D) imaging has risen to prominence in the field of developmental biology for its ability(More)
We report on the RTGrid project, which investigates approaches for using high-performance computing infrastructures, such as the grid, in order to reduce the turnaround time of Monte Carlo (MC) simulation-based radiotherapy treatment planning. The main aim of this project is to render accurate dose calculations using MC simulations clinically feasible. To(More)
The International Mouse Phenotyping Consortium (IMPC) is providing the world’s first functional catalogue of a mammalian genome by characterising a knockout mouse strain for every gene. A robust and highly structured informatics platform has been developed to systematically collate, analyse and disseminate the data produced by the IMPC. As the first phase(More)
In this paper, we discuss a structural approach to automatic performance modelling of skeleton based applications. This uses a synthesis of performance evaluation process algebra (pepa) and a pattern-oriented hierarchical expression scheme. Such approaches are important in parallel and distributed systems where the performance models must be updated(More)
The type system of a language guarantees that all of the operations on a set of data comply with the rules and conditions set by the language. While language typing is a fundamental requirement for any programming language, the typing of data that flow between processing elements within a workflow is currently being treated as optional. In this paper, we(More)
This paper describes the RTGrid distributed simulation framework for conformal radiotherapy. We introduce novel approaches through which several distributed computing technologies are made accessible to Monte Carlo simulations for radiotherapy dose calculations. Currently, radiotherapy treatment planning is typically performed on PCs and workstations which(More)
In this paper, we discuss a structural approach to automatic performance modelling of workflow systems. This uses a synthesis of performance evaluation process algebra (pepa) and a pattern-based hierarchical expression scheme. Such systems are important in cases where the performance models must be updated regularly, and dynamically, based on the current(More)