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We describe a promising non-invasive transdermal delivery system comprising block copolymer composite micelles that contained a phase-change material (PCM), photothermal Au nanoparticles (AuNPs), and hydrophobic drugs in the core. To minimize cell toxicity, we developed block copolymer micelles with a poly(ɛ-caprolactone) (PCL) biodegradable core and a(More)
BACKGROUND Many inflammatory mediators, including various cytokines (e.g. interleukins and tumor necrosis factor [TNF]), inflammatory proteases, and histamine are released following mast cell activation. However, the endogenous modulators for mast cell activation and the underlying mechanism have yet to be elucidated. Endogenous cannabinoids such as(More)
In evaluating the safety of a novel cosmetic product or a new chemical, it is important to assess susceptible population. One group of subjects is known to stingers who are more likely to experience sensory effects such as stinging and burning after contacting with cosmetics. The purpose of the study is to measure skin biophysical parameters noninvasively(More)
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