Learn More
The maintenance of H3K9 and DNA methylation at imprinting control regions (ICRs) during early embryogenesis is key to the regulation of imprinted genes. Here, we reveal that ZFP57, its cofactor KAP1, and associated effectors bind selectively to the H3K9me3-bearing, DNA-methylated allele of ICRs in ES cells. KAP1 deletion induces a loss of heterochromatin(More)
BACKGROUND Differentially methylated regions (DMRs) are associated with many imprinted genes. In mice methylation at a DMR upstream of the H19 gene known as the Imprint Control region (IC1) is acquired in the male germline and influences the methylation status of DMRs 100 kb away in the adjacent Insulin-like growth factor 2 (Igf2) gene through long-range(More)
The parent of origin-dependent expression of the IGF2 and H19 genes is controlled by the imprinting centre 1 (IC1) consisting in a methylation-sensitive chromatin insulator. Deletions removing part of IC1 have been found in patients affected by the overgrowth- and tumour-associated Beckwith-Wiedemann syndrome (BWS). These mutations result in the(More)
Isotopic distributions for light particles and intermediate mass fragments have been measured for isotone, and isobar yield ratios are utilized to estimate the isotopic composition of the gas phase at freeze-out. Analyses within the equilibrium limit imply that the gas phase is enriched in neutrons relative to the liquid phase represented by bound nuclei.(More)
This article describes the crystal selection and quality control utilized to develop and calibrate a high resolution array of CsI(Tl) scintillator crystals for the detection of energetic charged particles. Alpha sources are used to test the light output variation due to thallium doping gradients. Selection of crystals with better than 1% non-uniformity in(More)
  • U Lynen, R Bassini, M Begemann-Blaich, Th Blaich, H Emling, A Ferrero +27 others
  • 1996
The caloric curve of the highly excited projectile spectators emerging from peripheral collisions of two Au-nuclei at 600 AMeV was determined by measuring fragments and neutrons of its decay. This analysis will be reviewed and preliminary results obtained from the decay also of the target spectator will be presented.
  • V Serfling, C Schwarz, R Bassini, M Begemann-Blaich, S Fritz, S J Gaff +17 others
  • 2008
Breakup temperatures in central collisions of 197 Au + 197 Au at bombarding energies E/A = 50 to 200 MeV were determined with two methods. Isotope temperatures, deduced from double ratios of hydrogen, helium, and lithium isotopic yields, increase monotonically with bombarding energy from 5 MeV to 12 MeV, in qualitative agreement with a scenario of chemical(More)
A three parameter scaling relationship between isotopic distributions for elements with Z≤ 8 has been observed that allows a simple description of the dependence of such distributions on the overall isospin of the system. This scaling law (termed iso-scaling) applies for a variety of reaction mechanisms that are dominated by phase space, including(More)
Collisions of 112 Sn and 124 Sn nuclei, which differ in their isospin asymmetry, provide information about the rate of isospin diffusion and equilibration. Although several different probes can provide accurate diffusion measurements, the ratios of the mirror nuclei may be the simplest and most promising one. Ratios of the mass seven mirror nuclei yields(More)
Using symmetric 112Sn+112Sn, 124Sn+124Sn collisions as references, we probe isospin diffusion in peripheral asymmetric 112Sn+124Sn, 124Sn+112Sn systems at an incident energy of E/A=50 MeV. Isoscaling analyses imply that the quasiprojectile and quasitarget in these collisions do not achieve isospin equilibrium, permitting an assessment of isospin transport(More)