Gael Pérez-Rodríguez

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This paper presents the results of the BioCreative V.5 offline tasks related to the evaluation of the performance as well as assess progress made by strategies used for the automatic recognition of mentions of chemical names and gene in running text of medicinal chemistry patent abstracts. A total of 21 teams submitted results for at least one of these(More)
Chemoprevention is the use of natural and/or synthetic substances to block, reverse, or retard the process of carcinogenesis. In this field, the use of antitumor peptides is of interest as, (i) these molecules are small in size, (ii) they show good cell diffusion and permeability, (iii) they affect one or more specific molecular pathways involved in(More)
The TIPS track consisted in a novel experimental task under the umbrella of the BioCreative text mining challenges with the aim to, for the first time ever, carry out a text mining challenge with particular focus on the continuous assessment of technical aspects of text annotation web servers, specifically of biomedical online named entity recognition(More)
Methods for visualizing DNA damage at the microscopic level are based on treatment of cell nuclei with saline or alkaline solutions. These procedures for achieving chromatin dispersion produce halos that surround the nuclear remnants. We improved the fast halo assay for visualizing DNA breakage in cultured cells to create a simplified method for detection(More)
This work presents a molecular-scale agent-based model for the simulation of enzymatic reactions at experimentally measured concentrations. The model incorporates stochasticity and spatial dependence, using diffusing and reacting particles with physical dimensions. We developed strategies to adjust and validate the enzymatic rates and diffusion coefficients(More)
Agent-based modelling is being used to represent biological systems with increasing frequency and success. This paper presents the implementation of a new tool for biomolecular reaction modelling in the open source Multiagent Simulator of Neighborhoods framework. The rationale behind this new tool is the necessity to describe interactions at the molecular(More)
Agent-based simulations are increasingly popular in exploring and understanding cellular systems, but the natural complexity of these systems and the desire to grasp different modelling levels demand cost-effective simulation strategies and tools. In this context, the present paper introduces novel sequential and distributed approaches for the(More)
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