Learn More
Bulk of the penicillin produced is used as raw material for semi-synthetic penicillin (such as amoxicillin and ampicillin) and semi-synthetic cephalosporins (such as cephalexin and cefadroxil). In the present paper, an industrial penicillin V bioreactor train is optimized for multiple objectives simultaneously. An industrial train, comprising a bank of(More)
A kinetic model based on first principles, for β2-microglobulin, is presented to obtain precise parameter estimates for individual patient. To reduce the model complexity, the number of model parameters was reduced using a priori identifiability analysis. The model validity was confirmed with the clinical data of ten renal patients on post-dilution(More)
The paper describes a multiobjective optimization study for industrial styrene reactors using non-dominated sorting genetic algorithm (NSGA). Several two-and three-objective functions, namely, production, yield and selectivity of styrene, are considered for adiabatic as well as steam-injected styrene reactors. Pareto optimal (a set of equally good)(More)
BACKGROUND Maintenance hemodialysis (HD) patients universally suffer from excess toxin load. Hemodiafiltration (HDF) has shown its potential in better removal of small as well as large sized toxins, but its efficacy is restricted by inter-compartmental clearance. Intra-dialytic exercise on the other hand is also found to be effective for removal of toxins;(More)
An integrated framework of simulation and heuristics is proposed. The main emphasis is on vertical integration of simulation and heuristics which exploits the inherent interlink between them. By adopting this framework, simulators can be more efficiently utilized and they also offer invaluable support to the decisions taken by heuristics. This framework is(More)