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The Jacob and Monod scheme for the regulation of enzyme formation leads to the following relation between the relative rate of enzyme synthesis alpha and cellular effector concentration E (the lower sign is for repressible systems): log (alpha/1 - alpha - alpha(b)) = +/- n log [E] + log alpha(b) +/- log K(1). This equation permits linear plotting of(More)
A program to analyse the length and frequency distribution of specific base tracts in genomic sequences is described. The frequency of oligopurine.oligopyrimidine tracts (R.Y. tracts) in a data base of 163 transcribed genes is analysed and compared. The complete genomes of SV40 virus, N. tobacum chloroplast, yeast 2 micron plasmid, bacteriophage lambda,(More)
Abstract Previous studies in this laboratory and others have demonstrated both stimulation and inhibition of vasopressin release by norepinephrine. In other regions of the central nervous system, diverse effects of norepinephrine reflect activation of different types of adrenergic receptors and the interaction of norepinephrine with other regulatory(More)
The DNA of the centromere of chromosome IV (CEN4) of Saccharomyces cerevisiae is found to be sensitive to single-strand specific nuclease P1 when inserted into a negatively supercoiled plasmid. Fine mapping identifies two P1-sensitive segments: one segment maps to essential centromere element CDEI and bordering CDEII bases, and the other segment is located(More)
  • G Yagil
  • 1991
A DNA structure is defined as paranemic if the participating strands can be separated without mutual rotation of the opposite strands. The experimental methods employed to detect paranemic, unwound, DNA regions is described, including probing by single-strand specific nucleases (SNN), conformation-specific chemical probes, topoisomer analysis, NMR, and(More)